ArticleGenes and immunity2001
Genetic polymorphisms in molecules of innate immunity and susceptibility to infection with Wuchereria bancrofti in South India.
Article in Genes and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 148 citations in OpenAlex.
- NQO1, MPO, and the risk of lung cancer: a HuGE review.Genetics in medicine : official journal of the American College of Medical Genetics · 2005Pooled it
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- Chitotriosidase: a marker and modulator of lung disease.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Duplication mutation in CHIT1 gene is associated with poor response to medical therapy in patients affected with filarial chyluria.Bioinformation · 2020Article
- The Genetic Polymorphisms of 24 Base Pair Duplication and Point G102S of Human Chitotriosidase to Bancroftian Filariasis at the Thai⁻Myanmar Border.Pathogens (Basel, Switzerland) · 2019Article
- Association of aThe American journal of tropical medicine and hygiene · 2019Article
- Genetic association of MBL-2 gene polymorphisms with Filarial chyluria.Bioinformation · 2019Article
- Regulation and Role of Chitotriosidase during Lung Infection withJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Single nucleotide polymorphisms in the angiogenic and lymphangiogenic pathways are associated with lymphedema caused by Wuchereria bancrofti.Human genomics · 2017Article
- Does 24bp Duplication of HumanJournal of clinical and diagnostic research : JCDR · 2016Article
- A comprehensive in silico analysis of non-synonymous and regulatory SNPs of human MBL2 gene.SpringerPlus · 2016Article
- Particularities of allergy in the Tropics.The World Allergy Organization journal · 2016Review
- Immunomodulatory Effects of Chitotriosidase Enzyme.Enzyme research · 2016Review
- Associations between Single Nucleotide Polymorphisms of High Mobility Group Box 1 Protein and Clinical Outcomes in Korean Sepsis Patients.Yonsei medical journal · 2016Article
- Article
- Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection.PLoS pathogens · 2015Article
- Chitotriosidase in the Pathogenesis of Inflammation, Interstitial Lung Diseases and COPD.Allergy, asthma & immunology research · 2015Review
- A Polymorphism in the Chitotriosidase Gene Associated with Risk of Mycetoma Due to Madurella mycetomatis Mycetoma--A Retrospective Study.PLoS neglected tropical diseases · 2015Article
- MBL-2 polymorphisms (codon 54 and Y-221X) and low MBL levels are associated with susceptibility to multi organ dysfunction in P. falciparum malaria in Odisha, India.Frontiers in microbiology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
A pilot study was conducted to determine if host genetic factors influence susceptibility and outcomes in human filariasis. Using the candidate gene approach, a well-characterized population in South India was studied using common polymorphisms in six genes (CHIT1, MPO, NRAMP, CYBA, NCF2, and MBL2). A total of 216 individuals from South India were genotyped; 67 normal (N), 63 asymptomatic microfilaria positive (MF+), 50 with chronic lymphatic dysfunction/elephantiasis (CP), and 36 tropical pulmonary eosinophilia (TPE). An association was observed between the HH variant CHIT1 genotype, which correlates with decreased activity and levels of chitotriosidase and susceptibility to filarial infection (MF+ and CP; P = 0.013). The heterozygosity of CHIT1 gene was over-represented in the normal individuals (P = 0.034). The XX genotype of the promoter region in MBL2 was associated with susceptibility to filariasis (P = 0.0093). Since analysis for MBL-sufficient vs insufficient haplotypes was not informative, it is possible the MBL2 promoter association results from linkage disequilibrium with neighboring loci. We have identified two polymorphisms, CHIT1 and MBL2 that are associated with susceptibility to human filarial infection, findings that merit further follow-up in a larger study.
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Registered trials
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