ReviewMicrobiology and molecular biology reviews : MMBR2001
Allosteric regulation of catalytic activity: Escherichia coli aspartate transcarbamoylase versus yeast chorismate mutase.
Review in Microbiology and molecular biology reviews : MMBR, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 72 citations in OpenAlex.
- Shikimate pathway disruption in yeast induces metabolite self-assembly into toxic aggregates.The FEBS journal · 2026Article
- Unique kinetic behavior of a secondary alcohol dehydrogenase: from a reaction engineering point of view.Bioprocess and biosystems engineering · 2026Article
- Stress Response in Bifidobacteria.Microbiology and molecular biology reviews : MMBR · 2022Review
- Adaptive evolution in the Saccharomyces kudriavzevii Aro4p promoted a reduced production of higher alcohols.Microbial biotechnology · 2022Article
- Genomic Insights Into Plant-Growth-Promoting Potentialities of the GenusFrontiers in microbiology · 2019Article
- Engineering Allostery into Proteins.Advances in experimental medicine and biology · 2019Review
- Stochastic protein multimerization, activity, and fitness.Physical review. E · 2018Article
- Transmembrane allosteric energetics characterization for strong coupling between proton and potassium ion binding in the KcsA channel.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Complex Formation between Two Biosynthetic Enzymes Modifies the Allosteric Regulatory Properties of Both: AN EXAMPLE OF MOLECULAR SYMBIOSIS.The Journal of biological chemistry · 2015Article
- The importance of chorismate mutase in the biocontrol potential of Trichoderma parareesei.Frontiers in microbiology · 2015Article
- Integrated transcriptomic and proteomic analysis of the bile stress response in a centenarian-originated probiotic Bifidobacterium longum BBMN68.Molecular & cellular proteomics : MCP · 2014Article
- Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme.Nature structural & molecular biology · 2011Article
- Silencing of Vlaro2 for chorismate synthase revealed that the phytopathogen Verticillium longisporum induces the cross-pathway control in the xylem.Applied microbiology and biotechnology · 2010Article
- Article
- High resolution approach to the native state ensemble kinetics and thermodynamics.Biophysical journal · 2008Article
- Hierarchical organization of eglin c native state dynamics is shaped by competing direct and water-mediated interactions.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Structures of open (R) and close (T) states of prephenate dehydratase (PDT)--implication of allosteric regulation by L-phenylalanine.Journal of structural biology · 2008Article
- Evolution of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase-encoding genes in the yeast Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Expression, purification, crystallization and preliminary X-ray crystallographic studies of a cold-adapted aspartate carbamoyltransferase from Moritella profunda.Acta crystallographica. Section F, Structural biology and crystallization communications · 2005Article
- New insights into allosteric mechanisms from trapping unstable protein conformations in silica gels.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Allosteric regulation of key metabolic enzymes is a fascinating field to study the structure-function relationship of induced conformational changes of proteins. In this review we compare the principles of allosteric transitions of the complex classical model aspartate transcarbamoylase (ATCase) from Escherichia coli, consisting of 12 polypeptides, and the less complicated chorismate mutase derived from baker's yeast, which functions as a homodimer. Chorismate mutase presumably represents the minimal oligomerization state of a cooperative enzyme which still can be either activated or inhibited by different heterotropic effectors. Detailed knowledge of the number of possible quaternary states and a description of molecular triggers for conformational changes of model enzymes such as ATCase and chorismate mutase shed more and more light on allostery as an important regulatory mechanism of any living cell. The comparison of wild-type and engineered mutant enzymes reveals that current textbook models for regulation do not cover the entire picture needed to describe the function of these enzymes in detail.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.