ArticleOncogene2001
Aberrant promoter methylation of previously unidentified target genes is a common abnormality in medulloblastomas--implications for tumor biology and potential clinical utility.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 93 citations in OpenAlex.
- Epigenetic regulation in medulloblastoma: from tumor heterogeneity to diagnostic, prognostic, and translational applications.Frontiers in molecular neuroscience · 2026Review
- Deregulated proliferation and differentiation in brain tumors.Cell and tissue research · 2015Review
- Epigenetic repression of the dopamine receptor D4 in pediatric tumors of the central nervous system.Journal of neuro-oncology · 2014Article
- The micro-RNA 199b-5p regulatory circuit involves Hes1, CD15, and epigenetic modifications in medulloblastoma.Neuro-oncology · 2012Article
- Establishment of Methylation-Specific PCR for the Mouse p53 Gene.Molecular biology international · 2011Article
- Promoter hypermethylation in prostate cancer.Cancer control : journal of the Moffitt Cancer Center · 2010Review
- DNA hypomethylation in cancer cells.Epigenomics · 2009Review
- Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation.Carcinogenesis · 2009Article
- Aberrant MGMT (O6-methylguanine-DNA methyltransferase) promoter methylation in choroid plexus tumors.Journal of neuro-oncology · 2009Article
- Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2.Neuro-oncology · 2008Article
- Biological background of pediatric medulloblastoma and ependymoma: a review from a translational research perspective.Neuro-oncology · 2008Review
- BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression.Cancer research · 2008Article
- SGNE1/7B2 is epigenetically altered and transcriptionally downregulated in human medulloblastomas.Oncogene · 2007Article
- Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis.Molecular and cellular biology · 2007Article
- Frequent but borderline methylation of p16 (INK4a) and TIMP3 in medulloblastoma and sPNET revealed by quantitative analyses.Journal of neuro-oncology · 2007Article
- Dickkopf-1 is an epigenetically silenced candidate tumor suppressor gene in medulloblastoma.Neuro-oncology · 2007Article
- Article
- Heparanase expression and TrkC/p75NTR ratios in human medulloblastoma.Clinical & experimental metastasis · 2006Article
- Molecular biology of medulloblastoma: will it ever make a difference to clinical management?Journal of neuro-oncology · 2005Article
- Promoter methylation pattern of caspase-8, P16INK4A, MGMT, TIMP-3, and E-cadherin in medulloblastoma.Pathology oncology research : POR · 2004Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Medulloblastomas exhibit an array of diverse cytogenetic abnormalities. To evaluate the significance of epigenetic rather than genetic lesions in medulloblastomas and other primitive neuroectodermal tumors (PNETs) of the childhood CNS we performed a systematic analysis of gene specific and global methylation. Methylation-specific PCR detected no methylation for p15(INK4B), von Hippel Lindau and TP53 and only limited methylation for E-Cadherin and p16(INK4A) in tumors. The cell lines Daoy and MHH-PNET-5 in which the p16(INK4A) promoter was methylated did not express the gene, but demonstrated abnormalities by SSCP. Immunohistochemistry for p16 was negative in all examined normal cerebella and medulloblastomas. Using the technique of Restriction Landmark Genomic Scanning we detected methylation affecting up to 1% of all CpG islands in primary MB/PNETs and 6% in MB cell lines. Methylation patterns differed between medulloblastomas and PNETs. Examination of several methylated sequences revealed homologies to known genes and expressed sequences. Analysis of survival data identified seven of 30 hypermethylated sequences significantly correlating with poor prognosis. We suggest that DNA hypermethylation has an outstanding potential for the identification of novel tumor suppressors as well as diagnostic and therapeutic targets in MBs and other PNETs of the CNS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.