ArticleOncogene2001
Cleavage of Fyn and Lyn in their N-terminal unique regions during induction of apoptosis: a new mechanism for Src kinase regulation.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
- The dualistic role of Lyn tyrosine kinase in immune cell signaling: implications for systemic lupus erythematosus.Frontiers in immunology · 2024Review
- Caspases help to spread the message via extracellular vesicles.The FEBS journal · 2023Review
- Review
- Roscovitine enhances all-Oncotarget · 2020Article
- The Two Isoforms of Lyn Display Different Intramolecular Fuzzy Complexes with the SH3 Domain.Molecules (Basel, Switzerland) · 2018Article
- Article
- Article
- ATP-competitive Plk1 inhibitors induce caspase 3-mediated Plk1 cleavage and activation in hematopoietic cell lines.Oncotarget · 2018Article
- O-GlcNAcylation is required for B cell homeostasis and antibody responses.Nature communications · 2017Article
- Physiological functions and clinical implications of the N-end rule pathway.Frontiers of medicine · 2016Review
- Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src.PloS one · 2016Article
- The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway.Oncotarget · 2014Article
- Phosphorylation of unique domains of Src family kinases.Frontiers in genetics · 2014Review
- Genetic deletion of CD36 enhances injury after acute neonatal stroke.Annals of neurology · 2012Article
- Functions of the Lyn tyrosine kinase in health and disease.Cell communication and signaling : CCS · 2012Article
- Severe thymic atrophy in a mouse model of skin inflammation accounts for impaired TNFR1 signaling.PloS one · 2012Article
- p59fyn is associated with the development of hepatic steatosis due to chronic ethanol consumption.Journal of clinical biochemistry and nutrition · 2011Article
- B cell signature during inactive systemic lupus is heterogeneous: toward a biological dissection of lupus.PloS one · 2011Article
- The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice.The EMBO journal · 2009Article
- Inhibition of imatinib-mediated apoptosis by the caspase-cleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells.Leukemia · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The members of the Src kinase family are expressed in a wide variety of tissues, but some of them such as Blk, Hck, Fgr, Lck and Lyn are found primarily in hematopoietic cells. In the present study, we have undertaken experiments to test whether Src kinase cleavage and relocation is a general mechanism during induction of apoptosis. Our results indicate that Fyn and Lyn are efficiently cleaved in their unique region in hematopoietic cells undergoing apoptosis. Fyn cleavage occurred in Fas-stimulated Jurkat T cells but Fyn and Lyn were also processed in the SKW6.4 B cell line. Inhibition of caspases by Z-VAD-fmk or Ac-DEVD-CHO totally prevented Fyn and Lyn cleavage in both intact cells and in vitro. Fyn and Lyn but not Lck, Src and Hck were processed in vitro by human recombinant caspase 3 and by cellular extracts prepared from Fas-stimulated cells. Single mutation of Asp 19 or Asp 18 in the unique N-terminal domains of Fyn and Lyn respectively abolished their cleavage and relocation into the cytoplasm of apoptotic cells. When immunoprecipitated from COS cells N-terminal deleted Src kinases exhibited increased enzymatic kinase activity toward enolase. Thus, cleavage of Fyn and Lyn during induction of apoptosis represents a new mechanism for the regulation of Src kinases that may have important functional and physiological consequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.