ReviewMolecular psychiatry2001
Genetic mechanisms of behavior--don't forget about the transcription factors.
Review in Molecular psychiatry, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 60 citations in OpenAlex.
- The regulatory role of AP-2β in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential.Cell & bioscience · 2022Review
- Interdisciplinary Approach to Biological and Health Implications in Selected Professional Competences.Brain sciences · 2022Review
- Influence ofBrain and behavior · 2017Article
- Transcription Factor Activating Protein-2β (TFAP-2β) genotype and symptoms of attention deficit hyperactivity disorder in relation to symptoms of depression in two independent samples.European child & adolescent psychiatry · 2014Article
- Born to Lead? A Twin Design and Genetic Association Study of Leadership Role Occupancy.The leadership quarterly · 2013Article
- Genes, Economics, and Happiness.Journal of neuroscience, psychology, and economics · 2012Article
- Two-part random effects growth modeling to identify risks associated with alcohol and cannabis initiation, initial average use and changes in drug consumption in a sample of adult, male twins.Drug and alcohol dependence · 2012Article
- The dynorphin/κ-opioid receptor system and its role in psychiatric disorders.Cellular and molecular life sciences : CMLS · 2012Review
- Platelet monoamine oxidase activity predicts alcohol sensitivity and voluntary alcohol intake in rhesus monkeys.Upsala journal of medical sciences · 2010Article
- Transcription factor AP-2 beta genotype and psychosocial adversity in relation to adolescent depressive symptomatology.Journal of neural transmission (Vienna, Austria : 1996) · 2009Article
- The molecular genetic architecture of human personality: beyond self-report questionnaires.Molecular psychiatry · 2006Review
- Transcription factor AP-2 and monoaminergic functions in the central nervous system.Journal of neural transmission (Vienna, Austria : 1996) · 2005Review
- Brainstem levels of transcription factor AP-2 in rat are changed after treatment with phenelzine, but not with citalopram.BMC pharmacology · 2005Article
- Phenelzine treatment increases transcription factor AP-2 levels in rat brain.BMC pharmacology · 2003Article
- Association between a dinucleotide repeat polymorphism of the estrogen receptor alpha gene and personality traits in women.Molecular psychiatry · 2003Article
- Risk factors for the neurohumoral alterations underlying personality disturbances.Neurotoxicity researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major changes in psychiatric phenotypes due to genetic factors are seldom the result of single gene polymorphisms, but more often the result of several genetic mechanisms. In this millennium article we discuss the notion that the expression of numerous candidate genes could be regulated by the same transcription factors, and that polymorphisms in transcription factor genes might explain some phenotypes. We describe recent results of studies on the biological marker thrombocyte monoamine oxidase (trbc MAO) and the transcription factor AP-2beta. Low levels of trbc MAO is associated with temperamental characteristics such as sensation seeking and impulsiveness, and the enzyme is genetically regulated by specific transcriptional mechanisms. Transcription factor AP-2beta is important for the development of midbrain structures and AP-2beta has several binding sites in the regulatory regions of genes encoding key proteins in the monoamine transmitter systems. We have recently shown AP-2beta to be linked to personality, binge-eating disorder, treatment with antidepressant drugs, and also to trbc MAO. Regardless of whether transcriptions factors, such as AP-2beta, regulate the expression of eg, the number of monoamine neurons or a variety of candidate genes within the monoamine systems, or both, we would like to emphasize the role of transcription factors, besides polymorphisms in monoaminergic candidate genes, when explaining inter-individual differences in temperament and psychiatric vulnerability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.