ArticleProceedings of the National Academy of Sciences of the United States of America2001
Noninvasive neuroelectronic interfacing with synaptically connected snail neurons immobilized on a semiconductor chip.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 293 citations in OpenAlex.
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- In Situ Agarose Microfabrication Technology Using Joule Heating of Micro Ionic Current for On-Chip Cell Network Analysis.Micromachines · 2022Article
- Photothermal Agarose Microfabrication Technology for Collective Cell Migration Analysis.Micromachines · 2021Article
- In situ electroporation of mammalian cells through SiOScientific reports · 2021Article
- Stepwise neuronal network pattern formation in agarose gel during cultivation using non-destructive microneedle photothermal microfabrication.Scientific reports · 2021Article
- A neuronal wiring platform through microridges for rationally engineered neural circuits.APL bioengineering · 2020Article
- Instrumented Microphysiological Systems for Real-Time Measurement and Manipulation of Cellular Electrochemical Processes.iScience · 2019Review
- Human Brain/Cloud Interface.Frontiers in neuroscience · 2019Article
- Creating tissue on chip constructs in microtitre plates for drug discovery.RSC advances · 2018Article
- Capacitively Coupled Arrays of Multiplexed Flexible Silicon Transistors for Long-Term Cardiac Electrophysiology.Nature biomedical engineering · 2017Article
- A novel bio-mimicking, planar nano-edge microelectrode enables enhanced long-term neural recording.Scientific reports · 2016Article
- Insinuating electronics in the brain.The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland · 2016Review
- A neuron-in-capillary platform for facile collection and mass spectrometric characterization of a secreted neuropeptide.Scientific reports · 2016Article
- Current-Induced Transistor Sensorics with Electrogenic Cells.Biosensors · 2016Review
- In vitro studies of neuronal networks and synaptic plasticity in invertebrates and in mammals using multielectrode arrays.Neural plasticity · 2015Review
- Prospect of brain-machine interface in motor disabilities: the future support for multiple sclerosis patient to improve quality of life.Annals of medical and health sciences research · 2014Review
- Microfluidics-based in vivo mimetic systems for the study of cellular biology.Accounts of chemical research · 2014Article
- Cell patterning on photolithographically defined parylene-C: SiO2 substrates.Journal of visualized experiments : JoVE · 2014Article
- Augmentation-related brain plasticity.Frontiers in systems neuroscience · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A hybrid circuit of a semiconductor chip and synaptically connected neurons was implemented and characterized. Individual nerve cells from the snail Lymnaea stagnalis were immobilized on a silicon chip by microscopic picket fences of polyimide. The cells formed a network with electrical synapses after outgrowth in brain conditioned medium. Pairs of neurons were electronically interfaced for noninvasive stimulation and recording. Voltage pulses were applied to a capacitive stimulator on the chip to excite the attached neuron. Signals were transmitted in the neuronal net and elicited an action potential in a second neuron. The postsynaptic excitation modulated the current of a transistor on the chip. The implementation of the silicon-neuron-neuron-silicon circuit constitutes a proof-of-principle experiment for the development of neuroelectronic systems to be used in studies on neuronal signal processing, neurocomputation, and neuroprosthetics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.