ArticleProceedings of the National Academy of Sciences of the United States of America2001
Regulation of SR protein localization during development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Alternative splicing in stem cells and development: research progress and emerging technologies.Cell regeneration (London, England) · 2025Review
- Roles for the RNA-Binding Protein Caper in Reproductive Output inJournal of developmental biology · 2022Article
- Regulation of Survival Motor Neuron Gene Expression by Calcium Signaling.International journal of molecular sciences · 2021Article
- Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells.Biochimica et biophysica acta · 2014Article
- Multifunctional RNA processing protein SRm160 induces apoptosis and regulates eye and genital development in Drosophila.Genetics · 2014Article
- Splicosomal and serine and arginine-rich splicing factors as targets for TGF-β.Fibrogenesis & tissue repair · 2012Article
- The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.Molecular biology of the cell · 2012Article
- A family of RS domain proteins with novel subcellular localization and trafficking.Nucleic acids research · 2005Article
- Enod40, a short open reading frame-containing mRNA, induces cytoplasmic localization of a nuclear RNA binding protein in Medicago truncatula.The Plant cell · 2004Article
- Protein kinase A phosphorylation modulates transport of the polypyrimidine tract-binding protein.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Regulation and substrate specificity of the SR protein kinase Clk/Sty.Molecular and cellular biology · 2003Article
- Differential effects of hyperphosphorylation on splicing factor SRp55.The Biochemical journal · 2003Article
- Advances in the study of SR protein family.Genomics, proteomics & bioinformatics · 2003Review
- Multiple roles for SR proteins in trans splicing.Molecular and cellular biology · 2002Article
- Positive and negative modulation of human immunodeficiency virus type 1 Rev function by cis and trans regulators of viral RNA splicing.Journal of virology · 2002Article
- The RNAissance family: SR proteins as multifaceted regulators of gene expression.Wiley interdisciplinary reviews. RNAReview
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ser-Arg-rich (SR) proteins play numerous roles in spliceosome assembly and the regulation of splice-site selection. Whereas considerable attention has focused on the mechanistic details of SR protein activities, little is known concerning how these splicing regulators are controlled by the cell. Here we examined the subcellular localization of precursor mRNA splicing factors during early development of the nematode Ascaris lumbricoides. In the early embryo, before major zygotic gene activation, most SR proteins, along with RNA polymerase II, are localized in the cytoplasm. As development proceeds, we observe a significant decrease in the cytoplasmic levels of these factors and a concomitant increase in nuclear localization. In contrast, trimethylguanosine-capped small nuclear ribonucleoproteins are predominantly localized in the nucleus throughout this period. We previously showed that the phosphorylation state and activity of SR proteins are regulated during A. lumbricoides embryogenesis. These changes correlate with the onset of precursor mRNA splicing and zygotic transcription. Thus, a coordinate change in the subcellular localization of SR proteins and RNA polymerase II occurs at the transition from reliance on maternally deposited factors to embryonic expression. We propose that before zygotic gene activation, SR proteins and RNA polymerase II are stockpiled in the cytoplasm of early embryos, awaiting signals that lead to their activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.