ArticleJournal of clinical microbiology2001
Antifungal effects of lysozyme and lactoferrin against genetically similar, sequential Candida albicans isolates from a human immunodeficiency virus-infected southern Chinese cohort.
Article in Journal of clinical microbiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- Non-specific Protein and Peptide Antibacterial Factors of Mammals.The protein journal · 2026Review
- Salivary proteins modulate Candida albicans virulence and may prevent oropharingeal candidiasis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Regulation of antimicrobial peptides in Hermetia illucens in response to fungal exposure.Scientific reports · 2024Article
- Oral Mycobiome Alterations in Postmenopausal Women: Links to Inflammation, Xerostomia, and Systemic Health.Biomedicines · 2024Review
- Impact of Brief Exposure to Lysozyme and Lactoferrin on Pathogenic Attributes of Oral Candida.International dental journal · 2024Article
- Candida-associated denture stomatitis: clinical, epidemiological, and microbiological features.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Biomedical Applications of Lactoferrin on the Ocular Surface.Pharmaceutics · 2023Review
- Article
- In-depth investigation of microRNA-mediated cross-kingdom regulation between Asian honey bee and microsporidian.Frontiers in microbiology · 2022Article
- SARS-COV-2 and Ocular Surface: From Physiology to Pathology, a Route to Understand Transmission and Disease.Frontiers in physiology · 2021Review
- Improvement of the quality of buffalo's milk soft cheese by camel's whey protein concentrate.Journal of advanced veterinary and animal research · 2019Article
- Candida albicans Infection Model in Zebrafish (Danio rerio) for Screening Anticandidal Drugs.Mycopathologia · 2019Article
- Anticaries activity of egg ovalbumin in an experimental caries biofilm model on enamel and dentin.Clinical oral investigations · 2019Article
- The Golden Egg: Nutritional Value, Bioactivities, and Emerging Benefits for Human Health.Nutrients · 2019Review
- Impact of Brief Exposure to Drugs with Antifungal Properties on the Susceptibility of Oral Candida dubliniensis Isolates to Lysozyme and Lactoferrin.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2018Article
- RNA-sequence analysis of gene expression from honeybees (Apis mellifera) infected with Nosema ceranae.PloS one · 2017Article
- Generation of bi-transgenic pigs overexpressing human lactoferrin and lysozyme in milk.Transgenic research · 2015Article
- Oral lactoferrin protects against experimental candidiasis in mice.Journal of applied microbiology · 2015Article
- Comparative functional analysis of the human macrophage chitotriosidase.Protein science : a publication of the Protein Society · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A variety of innate defense factors in saliva such as lysozyme and lactoferrin contribute to mucosal protection and modulate Candida populations in the oral cavity. It is also known that in human immunodeficiency virus (HIV)-infected individuals significant variations in the concentrations of lysozyme and lactoferrin in saliva occur during disease progression. Therefore, the aim of this study was to determine the in vitro susceptibility to human lactoferrin and hen egg white lysozyme of genotypically similar oral Candida albicans isolates obtained from six HIV-infected ethnic Chinese during sequential visits over a 12-month period. The similarity of the genotypes (50 in total) was evaluated using a randomly amplified polymorphic DNA assay. A blastospore viability assay was performed to evaluate the sensitivity of the organisms to lysozyme and lactoferrin. Exposure to physiological concentrations of either lysozyme (30 microg/ml) or lactoferrin (20 microg/ml) caused a rapid loss of viability among all isolates to a varying extent. None of the sequential C. albicans isolates demonstrated significant differences in sensitivity to either protein from one visit to the next; similar results were noted when the different genotypes from the same individual were compared. On Spearman correlation analysis of two genotypes that were sequentially isolated from a single patient, a significant negative correlation between lysozyme (r = -0.88; P < 0.02) (but not lactoferrin) resistance and the duration of HIV disease was seen. These results imply that a minority of C. albicans isolates that persist intraorally in individuals with HIV disease develop progressive resistance to innate salivary antifungal defenses such as lysozyme, possibly as an adaptive response. However, the vast majority of the Candida isolates appear to succumb to these nonspecific host immune mediators abundantly present in the oral environment.
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