ArticleEvolution; international journal of organic evolution2001
Meiotic recombination, cross-reactivity, and persistence in Plasmodium falciparum.
Article in Evolution; international journal of organic evolution, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Evolution of tetraspanin antigens in the zoonotic Asian blood fluke Schistosoma japonicum.Parasites & vectors · 2023Article
- 5-methylcytosine modification byProceedings of the National Academy of Sciences of the United States of America · 2022Article
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- Evaluating the Performance of Malaria Genetics for Inferring Changes in Transmission Intensity Using Transmission Modeling.Molecular biology and evolution · 2021Article
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- Multiple var2csa-type PfEMP1 genes located at different chromosomal loci occur in many Plasmodium falciparum isolates.PloS one · 2009Article
- Plasmodium falciparum antigenic variation. Mapping mosaic var gene sequences onto a network of shared, highly polymorphic sequence blocks.Molecular microbiology · 2008Article
- Gametocytemia and fever in human malaria infections.The Journal of parasitology · 2007Article
- Dynamics of immune response and drug resistance in malaria infection.Malaria journal · 2006Article
- Antigenic diversity and immune evasion by malaria parasites.Clinical and diagnostic laboratory immunology · 2004Review
- Differential recognition of Plasmodium falciparum merozoite surface protein 2 variants by antibodies from malaria patients in Brazil.Clinical and diagnostic laboratory immunology · 2003Article
- Dynamics and selection of many-strain pathogens.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- A biologic basis for integrated malaria control.The American journal of tropical medicine and hygiene · 2002Article
- Plasmodium malariae infection boosts Plasmodium falciparum gametocyte production.The American journal of tropical medicine and hygiene · 2002Article
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5 authors.
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Abstract
We incorporate a representation of Plasmodium falciparum recombination within a discrete-event model of malaria transmission. We simulate the introduction of a new parasite genotype into a human population in which another genotype has reached equilibrium prevalence and compare the emergence and persistence of the novel recombinant forms under differing cross-reactivity relationships between the genotypes. Cross-reactivity between the parental (initial and introduced) genotypes reduces the frequency of appearance of recombinants within three years of introduction from 100% to 14%, and delays their appearance by more than a year, on average. Cross-reactivity between parental and recombinant genotypes reduces the frequency of appearance to 36% and increases the probability of recombinant extinction following appearance from 0% to 83%. When a recombinant is cross-reactive with its parental types, its probability of extinction is influenced by cross-reactivity between the parental types in the opposite manner; that is, its probability of extinction after appearance decreases. Frequencies of P. falciparum outcrossing are mediated by frequencies of mixed-genotype infections in the host population, which are in turn mediated by the structure of cross-reactivity between parasite genotypes. The three leading hypotheses about how meiosis relates to oocyst production lead to quantitative, but no qualitative, differences in these results.
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