ArticleCell stress & chaperones2001
The hsp60B gene of Drosophila melanogaster is essential for the spermatid individualization process.
Article in Cell stress & chaperones, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
- Molecular Chaperonin HSP60: Current Understanding and Future Prospects.International journal of molecular sciences · 2024Review
- Article
- Analysis of Drosophila melanogaster testis transcriptome.BMC genomics · 2018Article
- Molecular characteristics of a novel HSP60 gene and its differential expression in Manila clams (Ruditapes philippinarum) under thermal and hypotonic stress.Cell stress & chaperones · 2018Article
- Article
- FUS Interacts with HSP60 to Promote Mitochondrial Damage.PLoS genetics · 2015Article
- Molecular chaperones, cochaperones, and ubiquitination/deubiquitination system: involvement in the production of high quality spermatozoa.BioMed research international · 2014Review
- Molecular cloning of heat shock protein 60 (PtHSP60) from Portunus trituberculatus and its expression response to salinity stress.Cell stress & chaperones · 2012Article
- Article
- Hsp60D is essential for caspase-mediated induced apoptosis in Drosophila melanogaster.Cell stress & chaperones · 2008Article
- Evolutionary origin of regulatory regions of retrogenes in Drosophila.BMC genomics · 2008Article
- Comparative genomics reveals a constant rate of origination and convergent acquisition of functional retrogenes in Drosophila.Genome biology · 2007Article
- The Hsp27 gene is not required for Drosophila development but its activity is associated with starvation resistance.Cell stress & chaperones · 2007Article
- The Hsp60C gene in the 25F cytogenetic region in Drosophila melanogaster is essential for tracheal development and fertility.Journal of genetics · 2005Article
- Expression of the Hsp23 chaperone during Drosophila embryogenesis: association to distinct neural and glial lineages.BMC developmental biology · 2003Article
- Regulation of heat shock proteins, Hsp70 and Hsp64, in heat-shocked Malpighian tubules of Drosophila melanogaster larvae.Cell stress & chaperones · 2002Article
- Separating from the pack: Molecular mechanisms ofSpermatogenesisArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 60-kDa heat shock protein family (Hsp60) is found in prokaryotes, mitochondria, and chloroplasts. The Hsp60 proteins promote proper protein folding by preventing aggregation. In Drosophila melanogaster, the hsp60 gene is essential for a variety of developmental processes, beginning at early embryogenesis. In this study we show that an additional member of the Drosophila hsp60 gene family, hsp60B, is essential in male fertility. In males homozygous for a mutation of the hsp60B gene, developmental processes appeared normal throughout most of spermatogenesis, including spermatocyte growth, meiosis, and spermatid elongation. At these stages, mitochondria also displayed a differentiation process similar to wild-types. However, we found that the mutation disrupted a late stage of spermatogenesis, the spermatid individualization process. In this process, the individualization complex is assembled at spermatid nuclear heads, traverses along spermatid tails, and generates membranes for each of the spermatids in a cyst. Our analysis further shows that the individualization complex in sterile males displayed abnormal morphology as it was traveling along the spermatid tails. The Drosophila Hsp60 proteins are believed to be exclusively localized in the mitochondria. Our observation that the hsp60B mutation displayed no apparent defect in mitochondrial differentiation during spermatogenesis suggests that the Hsp60B protein may operate in a nonmitochondrial location.
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