ArticleCell stress & chaperones2001
Arsenite-inducible RNA-associated protein (AIRAP) protects cells from arsenite toxicity.
Article in Cell stress & chaperones, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Copper ionophore elicits calpain-dependent paraptosis coincident with proteotoxic stress.Cell communication and signaling : CCS · 2025Article
- Activators of the 26S proteasome when protein degradation increases.Experimental & molecular medicine · 2025Review
- Mechanisms of genotoxicity and proteotoxicity induced by the metalloids arsenic and antimony.Cellular and molecular life sciences : CMLS · 2023Review
- A novel endoplasmic reticulum adaptation is critical for the long-lived Caenorhabditis elegans rpn-10 proteasomal mutant.Biochimica et biophysica acta. Gene regulatory mechanisms · 2023Article
- Assessment of the effects of organic vs. inorganic arsenic and mercury inCurrent research in toxicology · 2022Article
- An Arsenite Relay between PSMD14 and AIRAP Enables Revival of Proteasomal DUB Activity.Biomolecules · 2021Article
- Copper toxicity of inflection point in human intestinal cell line Caco-2 dissected: influence of temporal expression patterns.In vitro cellular & developmental biology. Animal · 2021Article
- ZFAND5/ZNF216 is an activator of the 26S proteasome that stimulates overall protein degradation.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A Novel Destabilizing Domain Based on a Small-Molecule Dependent Fluorophore.ACS chemical biology · 2016Article
- Article
- Stress-induced start codon fidelity regulates arsenite-inducible regulatory particle-associated protein (AIRAP) translation.The Journal of biological chemistry · 2014Article
- The proteasome inhibitor bortezomib is a potent inducer of zinc finger AN1-type domain 2a gene expression: role of heat shock factor 1 (HSF1)-heat shock factor 2 (HSF2) heterocomplexes.The Journal of biological chemistry · 2014Article
- The ubiquitin proteasome system in Caenorhabditis elegans and its regulation.Redox biology · 2014Review
- Functional genomic assessment of phosgene-induced acute lung injury in mice.American journal of respiratory cell and molecular biology · 2013Article
- Arsenite tolerance in rice (Oryza sativa L.) involves coordinated role of metabolic pathways of thiols and amino acids.Environmental science and pollution research international · 2013Article
- Article
- A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target.Nature medicine · 2012Article
- Microarray genomic profile of mitochondrial and oxidant response in manganese chloride treated PC12 cells.Neurotoxicology · 2012Article
- Transgenic nematodes as biosensors for metal stress in soil pore water samples.Ecotoxicology (London, England) · 2012Article
- skn-1-Dependent and -independent regulation of aip-1 expression following metabolic stress in Caenorhabditis elegans.Molecular and cellular biology · 2010Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Exposure of cells to arsenicals activates multiple stress pathways resulting in the induction of specific genes whose identity and role in the adaptation to arsenical-induced cellular stress are poorly understood. We report here the identification of a novel gene encoding an arsenite-inducible, cysteine- and histidine-rich RNA-associated protein, AIRAP, that is conserved among mammals, Drosophila and C elegans. Immunochemistry and cell fractionation experiments indicate that, when induced, AIRAP is present in both the nucleus and the cytoplasm, and cross-linking experiments indicate that it associates with RNA in vivo. The expression of a C elegans homologue of AIRAP, aip-1, is also induced by exposure to arsenite, and expression of an aip-1::gfp transgene is most pronounced in hypodermal cells. RNA-mediated interference (RNAi) of aip-1 lowers the resistance of nematodes to arsenite yet does not appear to affect viability under standard growth conditions. These experiments suggest a role for AIRAP/AIP-1 in protecting cells from the toxic effects of arsenite.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.