ArticleAnnals of surgery2001
Clinical intestinal transplantation: a decade of experience at a single center.
Article in Annals of surgery, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 375 citations in OpenAlex.
- Guidelines for the assessment and acceptance of potential brain-dead organ donors.Revista Brasileira de terapia intensiva · 2016Guideline
- Intestinal and Multivisceral Transplantation: Where We Stand Today.Pediatric transplantation · 2026Review
- Update on Maintenance Immunosuppression in Intestinal Transplantation.Gastroenterology clinics of North America · 2024Review
- Chimerism-Mediated Tolerance in Intestinal Transplantation.Gastroenterology clinics of North America · 2024Review
- Combined Organ Transplantation in Patients with Advanced Liver Disease.Seminars in liver disease · 2024Review
- Anaesthesia for intestinal transplantation.BJA education · 2023Review
- Liver Inclusion Appears to Be Protective Against Graft Loss-Due-to Chronic But Not Acute Rejection Following Intestinal Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation.The Journal of clinical investigation · 2021Article
- Small bowel transplant: state-of-the-art vascular and nonvascular imaging.Abdominal radiology (New York) · 2020Review
- Utilization of Vicryl Bridging Mesh in Orthotopic Liver Transplantation to Achieve Tension-Free Abdominal Wall Closure: A Case Series.Case reports in surgery · 2020Article
- Transplant Critical Care: Is there a Need for Sub-specialized Units? - A Perspective.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2018Article
- Liver-inclusive intestinal transplantation results in decreased alloimmune-mediated rejection but increased infection.Gastroenterology report · 2018Article
- Choice of Allograft in Patients Requiring Intestinal Transplantation: A Critical Review.Canadian journal of gastroenterology & hepatology · 2017Review
- Protein-engineered scaffolds for in vitro 3D culture of primary adult intestinal organoids.Biomaterials science · 2015Article
- The concept of gut rehabilitation and the future of visceral transplantation.Nature reviews. Gastroenterology & hepatology · 2015Review
- Management of intestinal failure in inflammatory bowel disease: small intestinal transplantation or home parenteral nutrition?World journal of gastroenterology · 2014Review
- India's first successful intestinal transplant: the road traveled and the lessons learnt.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2014Review
- Engineering of three-dimensional microenvironments to promote contractile behavior in primary intestinal organoids.Integrative biology : quantitative biosciences from nano to macro · 2014Article
- Hypoxia enhances protective effect of placental-derived mesenchymal stem cells on damaged intestinal epithelial cells by promoting secretion of insulin-like growth factor-1.International journal of molecular sciences · 2014Article
- Isolated small bowel transplantation outcomes and the impact of immunosuppressants: Experience of a single transplant center.World journal of transplantation · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo assess the long-term efficacy of intestinal transplantation under tacrolimus-based immunosuppression and the therapeutic benefit of newly developed adjunct immunosuppressants and management strategies. SUMMARY BACKGROUND DATA: With the advent of tacrolimus in 1990, transplantation of the intestine began to emerge as therapy for intestinal failure. However, a high risk of rejection, with the consequent need for acute and chronic high-dose immunosuppression, has inhibited its widespread application.
methodsDuring an 11-year period, divided into two segments by a 1-year moratorium in 1994, 155 patients received 165 intestinal allografts under immunosuppression based on tacrolimus and prednisone: 65 intestine alone, 75 liver and intestine, and 25 multivisceral. For the transplantations since the moratorium (n = 99), an adjunct immunosuppressant (cyclophosphamide or daclizumab) was used for 74 transplantations, adjunct donor bone marrow was given in 39, and the intestine of 11 allografts was irradiated with a single dose of 750 cGy.
resultsThe actuarial survival rate for the total population was 75% at 1 year, 54% at 5 years, and 42% at 10 years. Recipients of liver plus intestine had the best long-term prognosis and the lowest risk of graft loss from rejection (P =.001). Since 1994, survival rates have improved. Techniques for early detection of Epstein-Barr and cytomegaloviral infections, bone marrow augmentation, the adjunct use of the interleukin-2 antagonist daclizumab, and most recently allograft irradiation may have contributed to the better results.
conclusionThe survival rates after intestinal transplantation have cumulatively improved during the past decade. With the management strategies currently under evaluation, intestinal transplant procedures have the potential to become the standard of care for patients with end-stage intestinal failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.