ReviewJournal of anatomy
Origin of the vertebrate inner ear: evolution and induction of the otic placode.
Review in Journal of anatomy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Single-cell, clonal and spatial atlases of cranial placodes illuminate their specification and evolution.bioRxiv : the preprint server for biology · 2026Article
- Article
- Bioelectronic Interfaces and Sensors for Neural Organoids.Microsystems & nanoengineering · 2025Review
- Molecular mechanisms of hearing loss in Nager syndrome.Developmental biology · 2021Article
- Morphology of the utricular otolith organ in the toadfish, Opsanus tau.The Journal of comparative neurology · 2018Article
- The mouse Foxi3 transcription factor is necessary for the development of posterior placodes.Developmental biology · 2016Article
- The role of foxi family transcription factors in the development of the ear and jaw.Current topics in developmental biology · 2015Review
- Segregating neural and mechanosensory fates in the developing ear: patterning, signaling, and transcriptional control.Cell and tissue research · 2015Review
- Setting appropriate boundaries: fate, patterning and competence at the neural plate border.Developmental biology · 2014Review
- Shaping sound in space: the regulation of inner ear patterning.Development (Cambridge, England) · 2012Review
- Sprouty1 and Sprouty2 limit both the size of the otic placode and hindbrain Wnt8a by antagonizing FGF signaling.Developmental biology · 2011Article
- Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice.Genes & development · 2008Review
- Lateral line, otic and epibranchial placodes: developmental and evolutionary links?Journal of experimental zoology. Part B, Molecular and developmental evolution · 2008Review
- Identification and developmental expression of two Tbx1/10-related genes in the agnathan Lethenteron japonicum.Development genes and evolution · 2007Article
- The role of the hindbrain in patterning of the otocyst.Developmental biology · 2007Review
- Expression of TGFbeta family in the developing internal ear of rat embryos.Journal of Korean medical science · 2006Article
- Expression patterns of astrocyte elevated gene-1 (AEG-1) during development of the mouse embryo.Gene expression patterns : GEPArticle
Corrections and comments
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Authors and funding
1 author.
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Abstract
The vertebrate inner ear forms a highly complex sensory structure responsible for the detection of sound and balance. Some new aspects on the evolutionary and developmental origin of the inner ear are summarised here. Recent molecular data have challenged the longstanding view that special sense organs such as the inner ear have evolved with the appearance of vertebrates. In addition, it has remained unclear whether the ear originally arose through a modification of the amphibian mechanosensory lateral line system or whether both evolved independently. A comparison of the developmental mechanisms giving rise to both sensory systems in different species should help to clarify some of these controversies. During embryonic development, the inner ear arises from a simple epithelium adjacent to the hindbrain, the otic placode, that is specified through inductive interactions with surrounding tissues. This review summarises the embryological evidence showing that the induction of the otic placode is a multistep process which requires sequential interaction of different tissues with the future otic ectoderm and the recent progress that has been made to identify some of the molecular players involved. Finally, the hypothesis is discussed that induction of all sensory placodes initially shares a common molecular pathway, which may have been responsible to generate an 'ancestral placode' during evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.