ArticleNucleic acids research2001
Inverted repeats as genetic elements for promoting DNA inverted duplication: implications in gene amplification.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Antibiotic use in oyster hatcheries promotes rapid spread of a highly transferable and modular resistance plasmid in Vibrio.The ISME journal · 2025Article
- Inverted repeats in the monkeypox virus genome are hot spots for mutation.Journal of medical virology · 2023Article
- The complexity landscape of viral genomes.GigaScience · 2022Article
- Morphology and Mitochondrial Genome of Fischoederius sp. 1 in Thailand.The Korean journal of parasitology · 2021Article
- Two New M23 Peptidoglycan Hydrolases With Distinct Net Charge.Frontiers in microbiology · 2021Article
- Lirex: A Package for Identification of Long Inverted Repeats in Genomes.Genomics, proteomics & bioinformatics · 2017Article
- Formation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nuclease.PLoS genetics · 2014Article
- Large inverted duplications in the human genome form via a fold-back mechanism.PLoS genetics · 2014Article
- Francisella tularensis Subtype A.II Genomic Plasticity in Comparison with Subtype A.I.PloS one · 2014Article
- Probing mercury(II)-DNA interactions by nanopore stochastic sensing.The journal of physical chemistry. B · 2013Article
- Article
- A framework for automated enrichment of functionally significant inverted repeats in whole genomes.BMC bioinformatics · 2010Article
- E. coli SbcCD and RecA control chromosomal rearrangement induced by an interrupted palindrome.Molecular cell · 2010Article
- The presence of distal and proximal promoters for rat mitochondrial glycerol-3-phosphate acyltransferase.Archives of biochemistry and biophysics · 2008Article
- On the paucity of duplicated genes in Caenorhabditis elegans operons.Journal of molecular evolution · 2006Article
- Double-strand breaks in the myotonic dystrophy type 1 and the fragile X syndrome triplet repeat sequences induce different types of mutations in DNA flanking sequences in Escherichia coli.Nucleic acids research · 2006Article
- A mechanism of palindromic gene amplification in Saccharomyces cerevisiae.Genes & development · 2005Article
- The structure and early evolution of recently arisen gene duplicates in the Caenorhabditis elegans genome.Genetics · 2003Article
- Diverse sequences within Tlr elements target programmed DNA elimination in Tetrahymena thermophila.Eukaryotic cell · 2003Article
- Suppression of gene amplification and chromosomal DNA integration by the DNA mismatch repair system.Nucleic acids research · 2001Article
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4 authors.
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Abstract
Inverted repeats are important genetic elements for genome instability. In the current study we have investigated the role of inverted repeats in a DNA rearrangement reaction using a linear DNA substrate. We show that linear DNA substrates with terminal inverted repeats can efficiently transform Escherichia coli. The transformation products contain circular inverted dimers in which the DNA sequences between terminal inverted repeats are duplicated. In contrast to the recombination/rearrangement product of circular DNA substrates, which is exclusively one particular form of the inverted dimer, the rearrangement products of the linear DNA substrate consist of two isomeric forms of the inverted dimer. Escherichia coli mutants defective in RecBCD exhibit much reduced transformation efficiency, suggesting a role for RecBCD in the protection rather than destruction of these linear DNA substrates. These results suggest a model in which inverted repeats near the ends of a double-strand break can be processed by a helicase/exonuclease to form hairpin caps. Processing of hairpin capped DNA intermediates can then yield inverted duplications. Linear DNA substrates containing terminal inverted repeats can also be converted into inverted dimers in COS cells, suggesting conservation of this type of genome instability from bacteria to mammalian cells.
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