ArticleBritish journal of pharmacology2001
Dependency of detrusor contractions on calcium sensitization and calcium entry through LOE-908-sensitive channels.
Article in British journal of pharmacology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 58 citations in OpenAlex.
- The role of rhoA/rho-kinase and PKC in the inhibitory effect of L-cysteine/HNaunyn-Schmiedeberg's archives of pharmacology · 2023Article
- Drugs Currently Undergoing Preclinical or Clinical Trials for the Treatment of Overactive Bladder: A Review.Current therapeutic research, clinical and experimental · 2022Review
- Lack of transient receptor potential vanilloid 1 channel modulates the development of neurogenic bladder dysfunction induced by cross-sensitization in afferent pathways.Journal of neuroinflammation · 2013Article
- Contribution of Rho-kinase to membrane excitability of murine colonic smooth muscle.British journal of pharmacology · 2011Article
- Evidence that actomyosin cross bridges contribute to "passive" tension in detrusor smooth muscle.American journal of physiology. Renal physiology · 2010Article
- Rhythmic contraction generates adjustable passive stiffness in rabbit detrusor.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- Carbachol-induced rabbit bladder smooth muscle contraction: roles of protein kinase C and Rho kinase.American journal of physiology. Renal physiology · 2009Article
- Adaptation of the length-active tension relationship in rabbit detrusor.American journal of physiology. Renal physiology · 2009Article
- Stimulated calcium entry and constitutive RhoA kinase activity cause stretch-induced detrusor contraction.European journal of pharmacology · 2008Article
- Signal transduction underlying the control of urinary bladder smooth muscle tone by muscarinic receptors and beta-adrenoceptors.Naunyn-Schmiedeberg's archives of pharmacology · 2008Review
- Muscarinic receptors: what we know.Current urology reports · 2003Review
- Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle.British journal of pharmacology · 2003Article
- RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction.British journal of pharmacology · 2002Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The subcellular mechanisms regulating stimulus-contraction coupling in detrusor remain to be determined. We used Ca(2+)-free solutions, Ca(2+) channel blockers, cyclopiazonic acid (CPA), and RhoA kinase (ROK) inhibitors to test the hypothesis that Ca(2+) influx and Ca(2+) sensitization play primary roles. 2. In rabbit detrusor, peak bethanechol (BE)-induced force was inhibited 90% by incubation for 3 min in a Ca(2+)-free solution. By comparison, a 20 min incubation of rabbit femoral artery in a Ca(2+)-free solution reduced receptor-induced force by only 5%. 3. In detrusor, inhibition of sarcoplasmic reticular (SR) Ca(2+) release by 2APB, or depletion of SR Ca(2+) by CPA, inhibited BE-induced force by only 27%. The CPA-insensitive force was abolished by LaCl3. By comparison, 2APB inhibited receptor-induced force in rabbit femoral artery by 71%. 4. In the presence of the non-selective cation channel (NSCC) inhibitor, LOE-908, BE did not produce an increase in [Ca(2+)]i but did produce weak increases in myosin phosphorylation and force. 5. Inhibitors of ROK-induced Ca(2+) sensitization, HA-1077 and Y-27632, inhibited BE-induced force by approximately 50%, and in combination with LOE-908, nearly abolished force. 6. These data suggest that two principal muscarinic receptor-stimulated detrusor contractile mechanisms include NSCC activation, that elevates [Ca(2+)]i and ROK activation, that sensitizes cross bridges to Ca(2+).
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