ArticleBritish journal of pharmacology2001
A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus.
Article in British journal of pharmacology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 88 citations in OpenAlex.
- The Effects of Endogenous Cannabinoids on the Mammalian Respiratory System: A Scoping Review of Cyclooxygenase-Dependent Pathways.Cannabis and cannabinoid research · 2023Article
- Modulation of the Oxidative Stress and Lipid Peroxidation by Endocannabinoids and Their Lipid Analogues.Antioxidants (Basel, Switzerland) · 2018Review
- Next-generation sequencing of the human TRPV1 gene and the regulating co-players LTB4R and LTB4R2 based on a custom AmpliSeq™ panel.PloS one · 2017Article
- Lipidomic Analysis of Endocannabinoid Signaling: Targeted Metabolite Identification and Quantification.Neural plasticity · 2016Review
- Ethanolamide oxylipins of linolenic acid can negatively regulate Arabidopsis seedling development.The Plant cell · 2013Article
- Article
- Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Therapeutic implications of disorders of cell death signalling: membranes, micro-environment, and eicosanoid and docosanoid metabolism.British journal of pharmacology · 2012Review
- Cannabinoid as a neuroprotective strategy in perinatal hypoxic-ischemic injury.Neuroscience bulletin · 2011Review
- A cytochrome P450-derived epoxygenated metabolite of anandamide is a potent cannabinoid receptor 2-selective agonist.Molecular pharmacology · 2009Article
- The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6.The Journal of pharmacology and experimental therapeutics · 2008Article
- Interactions between CB(1) receptors and TRPV1 channels mediated by 12-HPETE are cytotoxic to mesencephalic dopaminergic neurons.British journal of pharmacology · 2008Article
- The complications of promiscuity: endocannabinoid action and metabolism.British journal of pharmacology · 2007Review
- The differential contractile responses to capsaicin and anandamide in muscle strips isolated from the rat urinary bladder.European journal of pharmacology · 2007Article
- Effect of olvanil and anandamide on vagal C-fiber subtypes in guinea pig lung.British journal of pharmacology · 2005Article
- Multiple actions of anandamide on neonatal rat cultured sensory neurones.British journal of pharmacology · 2004Article
- The endocannabinoid system: a general view and latest additions.British journal of pharmacology · 2004Review
- Anandamide and vanilloid TRPV1 receptors.British journal of pharmacology · 2003Review
- Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- The actions of anandamide on rat superficial medullary dorsal horn neurons in vitro.The Journal of physiology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
1. In the absence of indomethacin, anandamide did not contract the guinea-pig bronchus at concentrations up to 100 microM. In the presence of indomethacin (10 microM), anandamide induced concentration-related contractions with a pEC(50) value of 5.18+/-0.11. It was significantly less potent than capsaicin (pEC(50) 7.01+/-0.1). The anandamide uptake inhibitor AM404, produced only a 14.1+/-3.22% contraction at 100 microM. All experiments were conducted in the presence of PMSF (20 microM). 2. The vanilloid receptor antagonist, capsazepine (10 microM), significantly attenuated the contractile effect of anandamide, the response to 100 microM anandamide being 40.53+/-7.04% in the presence of vehicle and 1.57+/-8.93% in the presence of 10 microM capsazepine. The contractile actions of anandamide and AM404 were markedly enhanced by the peptidase inhibitor thiorphan. 3. The log concentration-response curve of anandamide was unaltered by the CB1 receptor antagonist, SR141716A. The pEC(50) values for anandamide were 4.88+/-0.08 and 5.17+/-0.19 in the presence of vehicle and SR141716A (1 microM) respectively. 4. The lipoxygenase inhibitors 5,8,11,14-eicosatetraynoic acid (ETYA) and 5,8,11 eicosatriynoic acid (ETI) reduced the effect of 100 microM anandamide from 34.7+/-1.9% (vehicle) to 7.7+/-5% (ETYA, 10 microM) and from 41.85+/-4.25% (n=6) (vehicle) to 10.31+/-3.54 (n=6) (ETI, 20 microM). Neither inhibitor significantly affected contraction of the tissue by substance P. 5. This study provides evidence that anandamide acts on vanilloid receptors in the guinea-pig isolated bronchus. These data raise the possibility that the contractile action of anandamide may be due, at least in part, to lipoxygenase metabolites of this fatty acid amide that are vanilloid receptor agonists.
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