ReviewLipids2001
Studies on effects of dietary fatty acids as related to their position on triglycerides.
Review in Lipids, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 256 citations in OpenAlex.
- Fatty acid regio-specificity of triacylglycerol molecules may affect plasma lipid responses to dietary fats-a randomised controlled cross-over trial.European journal of clinical nutrition · 2020Trial
- Trial
- Chylomicron and VLDL TAG structures and postprandial lipid response induced by lard and modified lard.Lipids · 2003Trial
- Digestibility and microbiota modulation by nuts and sunflower seeds in cystic fibrosis: an in vitro approach.European journal of nutrition · 2026Article
- Article
- Faecal lipid profile as a new marker of fat maldigestion, malabsorption and microbiota.Pediatric research · 2024Observational
- Assessment of the Stability and Nutritional Quality of Hemp Oil and Pumpkin Seed Oil Blends.Foods (Basel, Switzerland) · 2024Article
- Mechanical Properties and In Vitro Digestibility of Fermented Lentil and Quinoa Flour Food Prototypes for Older Adults.Nutrients · 2024Article
- In vitro digestion and culture in Caco-2 cells to assess the bioavailability of fatty acids: A case study in meat matrix enriched with ω-3 microcapsules.Food science & nutrition · 2024Article
- Article
- Structured Lipids Engineering for Health: Novel Formulations Enriched inMetabolites · 2023Review
- Effect of metabolic activity of lactic acid bacteria and propionibacteria on cheese protein digestibility and fatty acid profile.Scientific reports · 2023Article
- Oil Bodies from Chia (Foods (Basel, Switzerland) · 2023Article
- Exploring the Impact of Solid-State Fermentation on Macronutrient Profile and Digestibility in Chia (Foods (Basel, Switzerland) · 2022Article
- Impact of Dietary Palmitic Acid on Lipid Metabolism.Frontiers in nutrition · 2022Review
- Free-Range Feeding Alters Fatty Acid Composition at theAnimals : an open access journal from MDPI · 2021Article
- Association between faecal pH and fat absorption in children with cystic fibrosis on a controlled diet and enzyme supplements dose.Pediatric research · 2021Article
- Study of the In Vitro Digestion of Olive Oil Enriched or Not with Antioxidant Phenolic Compounds. Relationships between Bioaccessibility of Main Components of Different Oils and Their Composition.Antioxidants (Basel, Switzerland) · 2020Article
- Electrophilic fatty acid nitroalkenes are systemically transported and distributed upon esterification to complex lipids.Journal of lipid research · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article reviews published literature on how the stereospecific structure of dietary triglycerides may affect lipid metabolism in humans. Animal studies have shown enhanced absorption of fatty acids in the sn-2 position of dietary triglycerides. Increasing the level of the saturated fatty acid palmitic acid in the sn-2 position (e.g., by interesterification of the fat to randomize the positions of the fatty acids along the glycerol backbone) has been shown in rabbits to increase the atherogenic potential of the fat without impacting levels of blood lipids and lipoproteins. In contrast, enhancing the level of stearic acid in the sn-2 position has not been found to affect either atherogenic potential or levels of blood lipids and lipoproteins in rabbits. Fatty acids other than palmitic and stearic have not been studied systematically with respect to possible positional effects. A limited number of human studies have shown no significant effects of interesterified fats on blood lipid parameters. However, it is unknown whether modifying the stereospecific structure of dietary triglycerides would affect atherogenicity or other long-term health conditions in humans. It is possible that incorporation of palmitic acid into the sn-2 position of milk fat is beneficial to the human infant (as a source of energy for growth and development) but not to human adults. Additional research is needed to determine whether processes like interesterification, which can be used to alter physical parameters of dietary fats (e.g., melting characteristics), may result in favorable or unfavorable long-term effects in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.