ArticleEMBO reports2001
A novel muscle LIM-only protein is generated from the paxillin gene locus in Drosophila.
Article in EMBO reports, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
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- Immune system modulation & virus transmission during parasitism identified by multi-species transcriptomics of a declining insect biocontrol system.BMC genomics · 2024Article
- Dynamics of transcriptional (re)-programming of syncytial nuclei in developing muscles.BMC biology · 2017Article
- Paxillin genes and actomyosin contractility regulate myotome morphogenesis in zebrafish.Developmental biology · 2017Article
- Identification and functional analysis of healing regulators in Drosophila.PLoS genetics · 2015Article
- The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering.PLoS genetics · 2014Article
- The cytoskeletal regulator zyxin is required for viability in Drosophila melanogaster.Anatomical record (Hoboken, N.J. : 2007) · 2010Article
- Downstream of identity genes: muscle-type-specific regulation of the fusion process.Developmental cell · 2010Article
- The Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogaster.PloS one · 2010Article
- Scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs.BMC biology · 2009Article
- Prominent actin fiber arrays in Drosophila tendon cells represent architectural elements different from stress fibers.Molecular biology of the cell · 2008Article
- Minimal features of paxillin that are required for the tyrosine phosphorylation of focal adhesion kinase.The Biochemical journal · 2006Article
- Regulation of Rho and Rac signaling to the actin cytoskeleton by paxillin during Drosophila development.Molecular and cellular biology · 2005Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paxillin is a protein containing four LIM domains, and functions in integrin signaling. We report here that two transcripts are generated from the paxillin gene locus in Drosophila; one encodes a protein homolog of the vertebrate Paxillin (DPxn37), and the other a protein with only three LIM domains, partly encoded by its own specific exon (PDLP). At the myotendinous junctions of Drosophila embryos where integrins play important roles, both DPxn37 and PDLP are highly expressed with different patterns; DPxn37 is predominantly concentrated at the center of the junctions, whereas PDLP is highly enriched at neighboring sides of the junction centers, primarily expressed in the mesodermal myotubes. Northern blot analysis revealed that DPxn37 is ubiquitously expressed throughout the life cycle, whereas PDLP expression exhibits a biphasic pattern during development, largely concomitant with muscle generation and remodeling. Our results collectively reveal that a unique system exists in Drosophila for the generation of a novel type of LIM-only protein, highly expressed in the embryonic musculature, largely utilizing the Paxillin LIM domains.
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