ArticleEMBO reports2001
Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells.
Article in EMBO reports, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 107 citations in OpenAlex.
- Piezo1 Mechanotransduction in Skeletal Muscle: Convergence with Noncoding RNA Regulation in Myogenesis, Regeneration, and Sarcopenia.International journal of molecular sciences · 2026Review
- Sports-Related Genomic Predictors Are Associated with Athlete Status in Chinese Sprint/Power Athletes.Genes · 2024Article
- EZH2 modulates retinoic acid signaling to ensure myotube formation during development.FEBS letters · 2022Article
- ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion.Developmental cell · 2021Article
- The MEK5/ERK5 Pathway in Health and Disease.International journal of molecular sciences · 2021Review
- Construction of a chromosome-level genome assembly for genome-wide identification of growth-related quantitative trait loci inZoological research · 2021Article
- Map2k5-Deficient Mice Manifest Phenotypes and Pathological Changes of Dopamine Deficiency in the Central Nervous System.Frontiers in aging neuroscience · 2021Article
- Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults.Endocrinology and metabolism (Seoul, Korea) · 2020Article
- MEK5/ERK5 activation regulates colon cancer stem-like cell properties.Cell death discovery · 2019Article
- Haplotype Association of thePsychiatry investigation · 2018Article
- Iron, dopamine, genetics, and hormones in the pathophysiology of restless legs syndrome.Journal of neurology · 2017Review
- Astrocyte-specific overexpressed gene signatures in response to methamphetamine exposure in vitro.Journal of neuroinflammation · 2017Article
- Extracellular Signal-Regulated Kinase 5 is Required for Low-Concentration HBioMed research international · 2017Article
- Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.Acta crystallographica. Section D, Structural biology · 2016Article
- ERK2 and Akt are negative regulators of insulin and Tumor Necrosis Factor-α stimulated VCAM-1 expression in rat aorta endothelial cells.Journal of inflammation (London, England) · 2016Article
- ERK5 signalling pathway is essential for fluid shear stress-induced COX-2 gene expression in MC3T3-E1 osteoblast.Molecular and cellular biochemistry · 2015Article
- Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma.BMC cancer · 2015Article
- Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1.The EMBO journal · 2014Article
- Overexpression of MEKK2 is associated with colorectal carcinogenesis.Oncology letters · 2013Article
- Signaling mechanisms in mammalian myoblast fusion.Science signaling · 2013Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular signal regulated kinase 5 (ERK5) is a novel member of the mitogen-activated protein kinase (MAPK) family with a poorly defined physiological function. Since ERK5 and its upstream activator MEK5 are abundant in skeletal muscle we examined a function of the cascade during muscle differentiation. We show that ERK5 is activated upon induction of differentiation in mouse myoblasts and that selective activation of the pathway results in promoter activation of differentiation-specific genes. Moreover, myogenic differentiation is completely blocked when ERK5 expression is inhibited by antisense RNA. Thus, we conclude that the MEK5/ERK5 MAP kinase cascade is critical for early steps of muscle cell differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.