ArticleJournal of neurovirology2001
Localization of retrovirus in the central nervous system of a patient co-infected with HTLV-1 and HIV with HAM/TSP and HIV-associated dementia.
Article in Journal of neurovirology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Review
- Astrocytes as an HIV CNS reservoir: highlights and reflections of an NIMH-sponsored symposium.Journal of neurovirology · 2018Article
- Article
- A comparative study of human T-cell lymphotropic virus-associated myelopathy in HIV-positive and HIV-negative patients in KwaZulu-Natal.Southern African journal of HIV medicine · 2017Article
- The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.Cell death and differentiation · 2005Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Persons co-infected with HTLV-1 and HIV are at increased risk for neurologic disease. These patients may develop HAM/TSP and/or HIV-associated dementia. In this study, we localized cells infected with retrovirus in the central nervous system (CNS) of a patient with both HAM/TSP and HIV-associated dementia. HTLV-1 was localized to astrocytes and HIV to macrophage/microglia. There was no co-infection of a single cell phenotype in this patient. These data suggest that mechanisms other than co-infection of the same CNS cell may play a role in the development of neurologic disease in patients dual infected with HTLV-1 and HIV.
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