Trial reportJournal of neurovirology2001
Increased frequency of JC virus type 2 and of dual infection with JC virus type 1 and 2 in Italian progressive multifocal leukoencephalopathy patients.
Trial report in Journal of neurovirology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Increased frequency of JC virus type 2 and of dual infection with JC virus type 1 and 2 in Italian progressive multifocal leukoencephalopathy patients.Journal of neurovirology · 2001Trial
- Database and Statistical Analyses of Transcription Factor Binding Sites in the Non-Coding Control Region of JC Virus.Viruses · 2021Article
- Analysis of variability of urinary excreted JC virus strains in patients infected with HIV and healthy donors.Journal of neurovirology · 2018Article
- Detection and analysis of variants of JC polyomavirus in urine samples from HIV-1-infected patients in China's Zhejiang Province.The Journal of international medical research · 2018Article
- JC virus load in cerebrospinal fluid and transcriptional control region rearrangements may predict the clinical course of progressive multifocal leukoencephalopathy.Journal of cellular physiology · 2012Article
- Individuals infected with JC polyomavirus do not present detectable JC virus DNA in oropharyngeal fluids.The Journal of general virology · 2012Article
- Presence and expression of JCV early gene large T Antigen in the brains of immunocompromised and immunocompetent individuals.Journal of medical virology · 2008Article
- Reply to letter to the editor: "JC viremia and multiple sclerosis" by FocosiJournal of neurovirology · 2008Article
- Characterization of JC virus in cerebrospinal fluid from HIV-1 infected patients with progressive multifocal leukoencephalopathy: insights into viral pathogenesis and disease prognosis.Journal of neurovirology · 2007Article
- High prevalence of human polyomavirus JC VP1 gene sequences in pediatric malignancies.Cellular and molecular biology (Noisy-le-Grand, France) · 2007Article
- JC virus in the Irish population: significant increase of genotype 2 in immunocompromised individuals.Journal of neurovirology · 2006Article
- A case of a progressive multifocal leukoencephalopathy patient with four different JC virus transcriptional control region rearrangements in cerebrospinal fluid, blood, serum, and urine.Journal of neurovirology · 2005Article
- Molecular analysis of JC virus genotypes circulating among the Italian healthy population.Journal of neurovirology · 2003Article
- Molecular analysis of cerebrospinal fluid in viral diseases of the central nervous system.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2003Review
- Analysis of JC virus genotype distribution and transcriptional control region rearrangements in human immunodeficiency virus-positive progressive multifocal leukoencephalopathy patients with and without highly active antiretroviral treatment.Journal of neurovirology · 2003Article
- JC virus regulatory region tandem repeats in plasma and central nervous system isolates correlate with poor clinical outcome in patients with progressive multifocal leukoencephalopathy.Journal of virology · 2001Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To verify the possibility of different role of JC virus genotypes in the etiology of progressive multifocal leukoencephalopathy, we analysed several JC virus isolates amplified from AIDS patients with and without progressive multifocal leukoencephalopathy and healthy controls by nucleotide sequencing. Cerebrospinal fluid (CSF), peripheral blood mononuclear cells (PBMCs) and urine from 52 AIDS patients suffering from various neurological diseases including 21 cases of progressive multifocal leukoencephalopathy, and PBMCs and urine from healthy subjects were evaluated by nested polymerase chain reaction (PCR) for the presence of DNA belonging to the highly conserved large T antigen (LT) of JC virus. The different JC virus subtypes were identified by nucleotide sequence analysis of the virion protein (VP1) genomic region. JC virus DNA was detected in all the CSF samples from the progressive multifocal leukoencephalopathy patients, but not in the CSF from non-progressive multifocal leukoencephalopathy cases, while the frequency of JC virus DNA detection in the PBMCs and urine did not differ among the three groups studied. JC virus type 2 was detected only in progressive multifocal leukoencephalopathy patients, and in particular in 52.4% of their CSF samples. Moreover, in the CSF of 19.0% of the progressive multifocal leukoencephalopathy cases, dual infection with both JC virus types 1 and 2 was found. The data obtained in this study indicate that the unexpected involvement of JC virus type 2, a strain not common in Italy, and the high frequency of dual infection with both JC virus types 1 and 2 in progressive multifocal leukoencephalopathy CSF, can be indications of risk factors for progressive multifocal leukoencephalopathy development.
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