ArticleJournal of lipid research2001
17beta-Estradiol promotes the up-regulation of SR-BII in HepG2 cells and in rat livers.
Article in Journal of lipid research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 44 citations in OpenAlex.
- Scavenger Receptor Class A to E Involved in Various Cancers.Chonnam medical journal · 2020Review
- Human SR-BI and SR-BII Potentiate Lipopolysaccharide-Induced Inflammation and Acute Liver and Kidney Injury in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Scavenger Receptors: Emerging Roles in Cancer Biology and Immunology.Advances in cancer research · 2015Review
- Functional genomics of the human high-density lipoprotein receptor scavenger receptor BI: an old dog with new tricks.Current opinion in endocrinology, diabetes, and obesity · 2013Review
- Scavenger receptor class B member 1 protein: hepatic regulation and its effects on lipids, reverse cholesterol transport, and atherosclerosis.Hepatic medicine : evidence and research · 2011Review
- Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones.Nutrition & metabolism · 2010Article
- Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study.BMC medical genetics · 2010Article
- Scavenger receptor class B type I protein as an independent predictor of high-density lipoprotein cholesterol levels in subjects with hyperalphalipoproteinemia.The Journal of clinical endocrinology and metabolism · 2009Article
- Variants in scavenger receptor class B type I gene are associated with HDL cholesterol levels in younger women.Human heredity · 2007Article
- CLA-1 and its splicing variant CLA-2 mediate bacterial adhesion and cytosolic bacterial invasion in mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Human scavenger receptor class B type II (SR-BII) and cellular cholesterol efflux.The Biochemical journal · 2004Article
- Biphasic estradiol-induced AKT phosphorylation is modulated by PTEN via MAP kinase in HepG2 cells.Molecular biology of the cell · 2003Article
- Low high-density lipoprotein cholesterol: physiological background, clinical importance and drug treatment.Drugs · 2003Review
- Distinct nongenomic signal transduction pathways controlled by 17beta-estradiol regulate DNA synthesis and cyclin D(1) gene transcription in HepG2 cells.Molecular biology of the cell · 2002Article
Corrections and comments
- Retraction · 2013-04-01Falsification/Fabrication of Data · Falsification/Fabrication of Image · Investigation by Company/Institution · Investigation by ORI · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · · Article is Sep 2001 (vol. 42, iss. 9, no day given); Retraction is Apr 2013 (vol. 54, iss. 4, no day given); There are 2 Findings of Research Misconduct for this article (EJ Smart): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259741/ and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019594/;
- Commented on by
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- Retracted
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The scavenger receptor class B type I (SR-BI) binds to HDL and mediates the selective uptake of cholesterol esters from HDL to cells. SR-BII is an alternatively spliced product of the SR-BI gene that only differs in the C-terminal cytoplasmic domain. Previous studies with male mice demonstrated that SR-BII comprises about 12% of the total SR-BI/SR-BII present in liver. In the current studies we used a liver cell line, HepG2, and a rat estrogen replacement model to examine the effects of estrogen on the expression of SR-BII. HepG2 cells express SR-BI but not SR-BII. SR-BI/SR-BII - blocking antibodies demonstrated that HepG2 cells selectively internalize cholesterol esters in a SR-BI - dependent manner. Incubation of HepG2 cells with 10 pM of 17beta-estradiol for 12 h eliminated the expression of SR-BI and promoted the up-regulation of SR-BII. Radiolabeled HDL-binding studies demonstrated that 17beta-estradiol increased the number of HDL binding sites by 3-fold in HepG2 cells. However, 17beta-estradiol - treated cell internalized approximately 25% less cholesterol ester than vehicle-only-treated cells. The livers obtained from male rats and ovariectomized female rats contained SR-BI and a small amount of SR-BII. In contrast, the livers obtained from intact female rats and ovariectomized female rats receiving estrogen replacement contained SR-BII and a small amount of SR-BI. The amount of SR-BI and SR-BII in adrenal tissue was not affected by any of the experimental treatments. We conclude that estrogen up-regulates SR-BII in HepG2 cells and rat liver.
Indexed as
Identifiers
11518764W2340108705What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.