ArticleThe Journal of clinical investigation2001
A complex role for the progesterone receptor in the response to vascular injury.
Article in The Journal of clinical investigation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 44 citations in OpenAlex.
- Brain nuclear receptors and cardiovascular function.Cell & bioscience · 2023Review
- Low Progesterone and Low Estradiol Levels Associate With Abdominal Aortic Aneurysms in Men.The Journal of clinical endocrinology and metabolism · 2022Article
- Sex, Gender, and Sex Hormones in Pulmonary Hypertension and Right Ventricular Failure.Comprehensive Physiology · 2019Review
- Effect of chronic estradiol plus progesterone treatment on experimental arterial and venous thrombosis in mouse.PloS one · 2017Article
- Identification of small proline-rich repeat protein 3 as a novel atheroprotective factor that promotes adaptive Akt signaling in vascular smooth muscle cells.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
- Sex-specific modification of progesterone receptor expression by 17β-oestradiol in human cardiac tissues.Biology of sex differences · 2010Article
- Placental growth factor mediates aldosterone-dependent vascular injury in mice.The Journal of clinical investigation · 2010Article
- A mouse model to dissect progesterone signaling in the female reproductive tract and mammary gland.Genesis (New York, N.Y. : 2000) · 2010Article
- Prevention of coronary hyperreactivity in preatherogenic menopausal rhesus monkeys by transdermal progesterone.Arteriosclerosis, thrombosis, and vascular biology · 2004Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Clinical studies of hormone replacement therapy to prevent cardiovascular diseases have heightened interest in the cardiovascular effects of progestins. However, the role of the progesterone receptor (PR) in vascular biology has not been studied in vivo. We studied ovariectomized female PR knockout (PRKO) mice and their wild-type (WT) littermates using the mouse carotid artery injury model. Placebo-treated PRKO mice showed significantly greater vascular medial hypertrophy and vascular smooth muscle cell (VSMC) proliferation in response to vascular injury than did WT mice. Progesterone had no significant effect in the PRKO mice, but worsened the response to injury in WT mice. VSMCs cultured from PRKO mouse aortae were markedly hyperproliferative, and their growth was not affected by progesterone. In contrast to the in vivo findings, progesterone inhibited proliferation of WT-derived VSMCs. Furthermore, reintroduction of PR into PRKO-derived VSMCs using adenoviral methods restored progesterone-mediated inhibition of proliferation to these cells. This effect was reversed by the PR antagonist, RU 486. Thus, the effects of PR and progesterone differ markedly between cultured VSMCs and intact blood vessels. These data demonstrate a direct role for the PR in regulating the response to vascular injury and VSMC proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.