ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Agrin differentially regulates the rates of axonal and dendritic elongation in cultured hippocampal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 59 citations in OpenAlex.
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- PACSIN1, a Tau-interacting protein, regulates axonal elongation and branching by facilitating microtubule instability.The Journal of biological chemistry · 2012Article
- Agrin downregulation induced by nerve injury contributes to neuropathic pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Target-dependent regulation of neurotransmitter specification and embryonic neuronal calcium spike activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Transmembrane agrin regulates dendritic filopodia and synapse formation in mature hippocampal neuron cultures.Neuroscience · 2009Article
- Na,K-ATPase activity regulates AMPA receptor turnover through proteasome-mediated proteolysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Transmembrane form agrin-induced process formation requires lipid rafts and the activation of Fyn and MAPK.The Journal of biological chemistry · 2009Article
- Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth.Journal of cell science · 2009Article
- The yin-yang of dendrite morphology: unity of actin and microtubules.Molecular neurobiology · 2008Review
- Agrin expression during synaptogenesis induced by traumatic brain injury.Journal of neurotrauma · 2008Article
- Agrin induced morphological and structural changes in growth cones of cultured hippocampal neurons.Neuroscience · 2007Article
- Hippocampal dendritic arbor growth in vitro: regulation by Reelin-Disabled-1 signaling.Brain research · 2007Article
- Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2.Journal of cell science · 2005Article
- Control of axonal branching and synapse formation by focal adhesion kinase.Nature neuroscience · 2004Article
- The COOH-terminal domain of agrin signals via a synaptic receptor in central nervous system neurons.The Journal of cell biology · 2003Article
- Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, we examined the role of agrin in axonal and dendritic elongation in central neurons. Dissociated hippocampal neurons were grown in the presence of either recombinant agrin or antisense oligonucleotides designed to block agrin expression. Our results indicate that agrin differentially regulates axonal and dendritic growth. Recombinant agrin decreased the rate of elongation of main axons but induced the formation of axonal branches. On the other hand, agrin induced both dendritic elongation and dendritic branching. Conversely, cultured hippocampal neurons depleted of agrin extended longer, nonbranched axons and shorter dendrites when compared with controls. These changes in the rates of neurite elongation and branching were paralleled by changes in the composition of the cytoskeleton. In the presence of agrin, there was an upregulation of the expression of microtubule-associated proteins MAP1B, MAP2, and tau. In contrast, a downregulation of the expression of these MAPs was detected in agrin-depleted cells. Taken collectively, these results suggest an important role for agrin as a trigger of the transcription of neuro-specific genes involved in neurite elongation and branching in central neurons.
Indexed as
Identifiers
11517268PMC6763100W2114394286What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.