ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
A mutation of early photoreceptor development, mikre oko, reveals cell-cell interactions involved in the survival and differentiation of zebrafish photoreceptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- The roles of cytoplasmic dynein complex in various ocular disorders.Molecular medicine (Cambridge, Mass.) · 2026Review
- Progressive Photoreceptor Dysfunction and Age-Related Macular Degeneration-Like Features inCells · 2020Article
- Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities.Molecular neurodegeneration · 2019Article
- Article
- Luminescence- and nanoparticle-mediated increase of light absorption by photoreceptor cells: Converting UV light to visible light.Scientific reports · 2016Article
- NINL and DZANK1 Co-function in Vesicle Transport and Are Essential for Photoreceptor Development in Zebrafish.PLoS genetics · 2015Article
- Genetics of photoreceptor degeneration and regeneration in zebrafish.Cellular and molecular life sciences : CMLS · 2011Review
- Toward a better understanding of human eye disease insights from the zebrafish, Danio rerio.Progress in molecular biology and translational science · 2011Review
- Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development.Neural development · 2010Article
- Analysis of the retina in the zebrafish model.Methods in cell biology · 2010Article
- Zebrafish ale oko, an essential determinant of sensory neuron survival and the polarity of retinal radial glia, encodes the p50 subunit of dynactin.Development (Cambridge, England) · 2009Article
- What drives cell morphogenesis: a look inside the vertebrate photoreceptor.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Review
- Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradient.Cell · 2008Article
- Zebrafish: a model system for the study of eye genetics.Progress in retinal and eye research · 2008Review
- Mechanism of positioning the cell nucleus in vertebrate photoreceptors.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Zebrafish dou yan mutation causes patterning defects and extensive cell death in the retina.Developmental dynamics : an official publication of the American Association of Anatomists · 2007Article
- Genomic organization of zebrafish cone-rod homeobox gene and exclusion as a candidate gene for retinal degeneration in niezerka and mikre oko.Molecular vision · 2005Article
- Studying rod photoreceptor development in zebrafish.Physiology & behavior · 2005Review
- Control of cellular pattern formation in the vertebrate inner retina by homotypic regulation of cell-fate decisions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To gain insight into mechanisms involved in photoreceptor development, we characterized a zebrafish mutation in the mikre oko locus that produces early loss of photoreceptor cells. mikre oko photoreceptors lose their elongated morphology at the time of wild-type outer segment formation and undergo cell death within a few days. To investigate whether this phenotype involves cell-cell interaction defects, we performed analysis of genetically mosaic animals. Interactions of mikre oko photoreceptors with wild-type cells rescue several aspects of the mutant phenotype. When placed in a wild-type environment, mikre oko photoreceptor cells retain elongated morphology and survive longer. Moreover, although mutant mikre oko photoreceptor outer segments develop only infrequently and are usually disorganized, mikre oko cone and rod cells in mosaic retinas develop robust outer segments that closely resemble the wild type. In contrast to the outer segments, the proximal regions of mikre oko photoreceptor cells, including their inner segments, the nuclear regions, and the synaptic termini, retain the mutant appearance. mikre oko outer segment rescue is not mediated by interactions with the retinal pigment epithelium. These studies demonstrate that the differentiation of outer segments is surprisingly independent from the more proximal photoreceptor cell features and that outer segment development includes retinal pigment epithelium-independent cell-cell interactions.
Indexed as
Identifiers
11517263PMC6763086W1573633304What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.