ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
ATP is required at an early step in compensatory endocytosis in synaptic terminals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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Who cites it
38 citing papers in PubMed, 75 citations in OpenAlex.
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- Early Reduction in Mitochondrial Membrane Potential in Synaptic Mitochondria Contribute to Synaptic Pathology in the EAE Mouse Model of Multiple Sclerosis.International journal of molecular sciences · 2026Article
- Optimal neuromuscular performance requires motor neuron phosphagen kinases.The Journal of physiology · 2026Article
- From oversight to insight: the curious case of the endothelial insulin receptor.Blood vessels, thrombosis & hemostasis · 2026Review
- Synaptic Vesicle Glycoprotein 2A Knockout in Parvalbumin and Somatostatin Interneurons Drives Seizures in the Postnatal Mouse Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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- Syntaxin 3B: A SNARE Protein Required for Vision.International journal of molecular sciences · 2024Review
- The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Mitochondrial Mutations Can Alter Neuromuscular Transmission in Congenital Myasthenic Syndrome and Mitochondrial Disease.International journal of molecular sciences · 2023Review
- Calcium is reduced in presynaptic mitochondria of motor nerve terminals during neurotransmission in SMA mice.Human molecular genetics · 2021Article
- Two Pools of Vesicles Associated with Synaptic Ribbons Are Molecularly Prepared for Release.Biophysical journal · 2017Article
- Promotion of endocytosis efficiency through an ATP-independent mechanism at rat calyx of Held terminals.The Journal of physiology · 2017Article
- Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane.Nature communications · 2016Article
- The role of mitochondrially derived ATP in synaptic vesicle recycling.The Journal of biological chemistry · 2015Article
- Porosome in the Exocrine Pancreas: A Detailed EM Study suppressor.Discoveries (Craiova, Romania) · 2014Article
- Contributions of Bcl-xL to acute and long term changes in bioenergetics during neuronal plasticity.Biochimica et biophysica acta · 2014Review
- Rapid kinetics of endocytosis at rod photoreceptor synapses depends upon endocytic load and calcium.Visual neuroscience · 2014Article
- Synaptic vesicle exocytosis in hippocampal synaptosomes correlates directly with total mitochondrial volume.Journal of molecular neuroscience : MN · 2013Article
- Rapid synaptic vesicle endocytosis in cone photoreceptors of salamander retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Whole-terminal capacitance measurements were used to examine membrane retrieval that follows Ca(2+)-triggered exocytosis in single synaptic terminals. Exocytosis was followed by endocytosis only when the internal solution contained a hydrolyzable analog of ATP. ATP-gamma-S, a poorly hydrolyzable ATP analog, did not support endocytosis but instead produced a rapid and profound inhibition of membrane retrieval. Under similar conditions, the GTP analogs GTP-gamma-S and GDP-beta-S failed to block endocytosis, suggesting that ATP is the preferred substrate. Furthermore, the requirement for ATP was independent of the role of ATP in regulating intraterminal Ca(2+), and the role of Ca(2+) in endocytosis was different from that of ATP. The results suggest a direct, acute requirement for ATP hydrolysis in compensatory fast endocytosis in synaptic terminals. Given that the capacitance technique detects changes in membrane surface area, ATP must be required for the membrane fission step or at a step that is a prerequisite for membrane fission.
Indexed as
Identifiers
11517235PMC6763084W1857966900What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.