Trial reportThorax2001
Effects of inhaled salbutamol in exercising non-asthmatic athletes.
Trial report in Thorax, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Model-based meta-analysis of salbutamol pharmacokinetics and practical implications for doping control.CPT: pharmacometrics & systems pharmacology · 2022Pooled it
- The impact of exercise-induced bronchoconstriction on athletic performance: a systematic review.Sports medicine (Auckland, N.Z.) · 2014Pooled it
- β₂-Agonists and physical performance: a systematic review and meta-analysis of randomized controlled trials.Sports medicine (Auckland, N.Z.) · 2011Pooled it
- Salbutamol effects on systemic potassium dynamics during and following intense continuous and intermittent exercise.European journal of applied physiology · 2016Trial
- High-dose inhaled terbutaline increases muscle strength and enhances maximal sprint performance in trained men.European journal of applied physiology · 2014Trial
- Effects of β2-adrenergic stimulation on exercise capacity in normal subjects.European journal of applied physiology · 2011Trial
- Effects of acute salbutamol intake during supramaximal exercise in women.British journal of sports medicine · 2007Trial
- Inhaled albuterol increases estimated ventilatory capacity in nonasthmatic children without and with obesity.Respiratory physiology & neurobiology · 2021Article
- Exercise performance after salbutamol inhalation in non-asthmatic, non-athlete individuals: a randomised, controlled, cross-over trial.BMJ open sport & exercise medicine · 2018Article
- Beta2-Agonist Doping Control and Optical Isomer Challenges.Sports medicine (Auckland, N.Z.) · 2016Article
- The rush to adrenaline: drugs in sport acting on the beta-adrenergic system.British journal of pharmacology · 2008Review
- Do inhaled beta(2)-agonists have an ergogenic potential in non-asthmatic competitive athletes?Sports medicine (Auckland, N.Z.) · 2007Review
- Inhaled beta2 agonists and performance in competitive athletes.British journal of sports medicine · 2006Review
- Use of beta2 agonists in sport: are the present criteria right?British journal of sports medicine · 2006Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBeta-2 agonists such as salbutamol are used, not only by asthmatic athletes to prevent exercise induced asthma, but also by non-asthmatic athletes as a potentially ergogenic agent. We have investigated whether inhaled salbutamol enhances endurance performance in non-asthmatic athletes.
methodsA prospective double blind, randomised, three way crossover design was used to study the effects of 200 microg and 800 microg inhaled salbutamol versus a placebo in 12 trained triathletes. The treatments were compared in three identical cycle ergometer sessions at 85% of the predetermined maximal oxygen uptake. Lung function, endurance time, metabolic parameters (glucose, potassium, lactate, free fatty acid, and glycerol), and psychomotor performance were evaluated.
resultsNeither endurance time nor post-exercise bronchodilation were significantly different between the treatments. Metabolic parameters were affected by exercise but not by treatment.
conclusionsInhaled salbutamol, even in a high dose, did not have a significant effect on endurance performance in non-asthmatic athletes, although the bronchodilating effect of the drug at the beginning of exercise may have improved respiratory adaptation. Our results do not preclude an ergogenic effect of beta2 agonists given by other routes or for a longer period.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.