ArticleMolecular biology of the cell2001
Biogenesis of Golgi stacks in imaginal discs of Drosophila melanogaster.
Article in Molecular biology of the cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Analysis of cancer mutations introduced into theeLife · 2026Article
- A feedforward loop between JAK/STAT downstream target p115 and STAT in germline stem cells.Stem cell reports · 2023Article
- A distinct Golgi-targeting mechanism of dGM130 inFrontiers in molecular neuroscience · 2023Article
- Fringe-positive Golgi outposts unite temporal Furin 2 convertase activity and spatial Delta signal to promote dendritic branch retraction.Cell reports · 2022Article
- Local Secretory Trafficking Pathways in Neurons and the Role of Dendritic Golgi Outposts in Different Cell Models.Frontiers in molecular neuroscience · 2020Review
- Article
- Article
- Intracellular Golgi Complex organization reveals tissue specific polarity during zebrafish embryogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Golgi during development.Cold Spring Harbor perspectives in biology · 2011Review
- Article
- AP-1 and clathrin are essential for secretory granule biogenesis in Drosophila.Molecular biology of the cell · 2011Article
- Article
- Wolbachia bacteria reside in host Golgi-related vesicles whose position is regulated by polarity proteins.PloS one · 2011Article
- A modeling approach to the self-assembly of the Golgi apparatus.Biophysical journal · 2010Article
- Functional characterization of protein-sorting machineries at the trans-Golgi network in Drosophila melanogaster.Journal of cell science · 2010Article
- Article
- Drosophila myt1 is the major cdk1 inhibitory kinase for wing imaginal disc development.Genetics · 2008Article
- Discrete pulses of molting hormone, 20-hydroxyecdysone, during late larval development of Drosophila melanogaster: correlations with changes in gene activity.Developmental dynamics : an official publication of the American Association of Anatomists · 2006Article
- Distinct functional units of the Golgi complex in Drosophila cells.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- dGRASP localization and function in the early exocytic pathway in Drosophila S2 cells.Molecular biology of the cell · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We provide a detailed description of Golgi stack biogenesis that takes place in vivo during one of the morphogenetic events in the lifespan of Drosophila melanogaster. In early third-instar larvae, small clusters consisting mostly of vesicles and tubules were present in epithelial imaginal disk cells. As larvae progressed through mid- and late-third instar, these larval clusters became larger but also increasingly formed cisternae, some of which were stacked. In white pupae, the typical Golgi stack was observed. We show that larval clusters are Golgi stack precursors by 1) localizing various Golgi-specific markers to the larval clusters by electron and immunofluorescence confocal microscopy, 2) driving this conversion in wild-type larvae incubated at 37 degrees C for 2 h, and 3) showing that this conversion does not take place in an NSF1 mutant (comt 17). The biological significance of this conversion became clear when we found that the steroid hormone 20-hydroxyecdysone (ecdysone) is critically involved in this conversion. In its absence, Golgi stack biogenesis did not occur and the larval clusters remained unaltered. We showed that dGM130 and sec23p expression increases approximately three- and fivefold, respectively, when discs are exposed to ecdysone in vivo and in vitro. Taken together, these results suggest that we have developed an in vivo system to study the ecdysone-triggered Golgi stack biogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.