ArticleMolecular biology of the cell2001
A conserved mechanism of synaptogyrin localization.
Article in Molecular biology of the cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 24 citations in OpenAlex.
- LRK-1/LRRK2 and AP-3 regulate trafficking of synaptic vesicle precursors through active zone protein SYD-2/Liprin-α.PLoS genetics · 2024Article
- The recurrent pathogenic Pro890Leu substitution in CLTC causes a generalized defect in synaptic transmission inFrontiers in molecular neuroscience · 2023Article
- pOpsicle: An all-optical reporter system for synaptic vesicle recycling combining pH-sensitive fluorescent proteins with optogenetic manipulation of neuronal activity.Frontiers in cellular neuroscience · 2023Article
- Synaptic Vesicle Precursors and Lysosomes Are Transported by Different Mechanisms in the Axon of Mammalian Neurons.Cell reports · 2020Article
- Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Netrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10, and the actin cytoskeleton.The Journal of cell biology · 2012Article
- Optimisation of over-expression in E. coli and biophysical characterisation of human membrane protein synaptogyrin 1.PloS one · 2012Article
- Caenorhabditis elegans aristaless/Arx gene alr-1 restricts variable gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- A role for myosin VI in the localization of axonal proteins.PLoS biology · 2011Article
- The C2H2 zinc-finger protein SYD-9 is a putative posttranscriptional regulator for synaptic transmission.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- SYNGR1 is associated with schizophrenia and bipolar disorder in southern India.Journal of human genetics · 2005Article
- Mutations in Caenorhabditis elegans cytoplasmic dynein components reveal specificity of neuronal retrograde cargo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Latrophilin is required for toxicity of black widow spider venom in Caenorhabditis elegans.The Biochemical journal · 2004Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied the localization of synaptogyrin family members in vivo. Both native and green fluorescent protein (GFP)-tagged Caenorhabditis elegans synaptogyrin (SNG-1) are expressed in neurons and synaptically localized. Deletion and mutational analysis with the use of GFP-tagged SNG-1 has defined a 38 amino acid sequence within the C terminus of SNG-1 and a single arginine in the cytoplasmic loop between transmembrane domain 2 and 3 that are required for SNG-1 localization. These domains may represent components of signals that target synaptogyrin for endocytosis from the plasma membrane and direct synaptogyrin to synaptic vesicles, respectively. In chimeric studies, these regions were sufficient to relocalize cellugyrin, a nonneuronal form of synaptogyrin, from nonsynaptic regions such as the sensory dendrites and the cell body to synaptic vesicles. Furthermore, GFP-tagged rat synaptogyrin is synaptically localized in neurons of C. elegans and in cultured hippocampal neurons. Similarly, the C-terminal domain of rat synaptogyrin is necessary for localization in hippocampal neurons. Our study suggests that the mechanisms for synaptogyrin localization are likely to be conserved from C. elegans to vertebrates.
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