ArticleThe Journal of experimental medicine2001
Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail.
Article in The Journal of experimental medicine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 119 citations in OpenAlex.
- Role of inhibitory signaling in peripheral B cell tolerance.Immunological reviews · 2022Review
- H3K36 methyltransferase NSD1 is essential for normal B1 and B2 cell development and germinal center formation.Frontiers in immunology · 2022Article
- Aging-dependent regulatory cells emerge in subcutaneous fat to inhibit adipogenesis.Developmental cell · 2021Article
- CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- CtIP is essential for early B cell proliferation and development in mice.The Journal of experimental medicine · 2019Article
- Continuous signaling of CD79b and CD19 is required for the fitness of Burkitt lymphoma B cells.The EMBO journal · 2018Article
- Molecular characterization of the CD79a and CD79b and its role against Aeromonas hydrophila infection in Chinese sucker (Myxocyprinus asiaticus).Fish physiology and biochemistry · 2017Article
- Article
- Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation.Nature communications · 2017Article
- Mechanisms of central tolerance for B cells.Nature reviews. Immunology · 2017Review
- Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses.Cell death and differentiation · 2016Article
- Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.Cell death and differentiation · 2016Article
- Reactivation of IgG-switched memory B cells by BCR-intrinsic signal amplification promotes IgG antibody production.Nature communications · 2015Article
- Modulation of Igβ is essential for the B cell selection in germinal center.Scientific reports · 2015Article
- Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia.Nature immunology · 2014Article
- Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects.PloS one · 2013Article
- B-cell receptor pathobiology and targeting in NHL.Current oncology reports · 2012Review
- Cannabinoid receptor 2 is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Lyn-mediated SHP-1 recruitment to CD5 contributes to resistance to apoptosis of B-cell chronic lymphocytic leukemia cells.Leukemia · 2011Article
- Cytoplasmic Ig alpha serine/threonines fine-tune Ig alpha tyrosine phosphorylation and limit bone marrow plasma cell formation.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine the function of immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation, we generated mice in which Igalpha ITAM tyrosines were replaced by phenylalanines (Igalpha(FF/FF)). Igalpha(FF/FF) mice had a specific reduction of B1 and marginal zone B cells, whereas B2 cell development appeared to be normal, except that lambda1 light chain usage was increased. The mutants responded less efficiently to T cell-dependent antigens, whereas T cell-independent responses were unaffected. Upon B cell receptor ligation, the cells exhibited heightened calcium flux, weaker Lyn and Syk tyrosine phosphorylation, and phosphorylation of Igalpha non-ITAM tyrosines. Strikingly, when the Igalpha ITAM mutation was combined with a truncation of Igbeta, B cell development was completely blocked at the pro-B cell stage, indicating a crucial role of ITAM phosphorylation in B cell development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.