ArticleThe Journal of experimental medicine2001
Positive selection of CD4(+) T cells is induced in vivo by agonist and inhibited by antagonist peptides.
Article in The Journal of experimental medicine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Dormant pathogenic CD4Nature communications · 2019Article
- TGF-β-mediated enhancement of TScience signaling · 2018Article
- Article
- Altered connexin 43 expression underlies age-dependent decrease of regulatory T cell suppressor function in nonobese diabetic mice.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- On the issue of peptide recognition in T cell development.Self/nonself · 2010Article
- The specific T-cell response to antigenic peptides is influenced by bystander peptides.Cellular & molecular biology letters · 2006Article
- An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4.The Journal of experimental medicine · 2005Article
- New approaches to eliciting protective immunity through T cell repertoire manipulation: the concept of thymic vaccination.Medical immunology (London, England) · 2004Article
- Functional reprogramming of the primary immune response by T cell receptor antagonism.The Journal of experimental medicine · 2004Article
- Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Presentation of antagonist peptides to naive CD4+ T cells abrogates spatial reorganization of class II MHC peptide complexes on the surface of dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The nature of peptides that positively select T cells in the thymus remains poorly defined. Here we report an in vivo model to study the mechanisms of positive selection of CD4(+) T cells. We have restored positive selection of TCR transgenic CD4(+) thymocytes, arrested at the CD4(+)CD8(+) stage, due to the lack of the endogenously selecting peptide(s), in mice deficient for H2-M and invariant chain. A single injection of soluble agonist peptide(s) initiated positive selection of CD4(+) transgenic T cells that lasted for up to 14 days. Positively selected CD4(+) T cells repopulated peripheral lymphoid organs and could respond to the antigenic peptide. Furthermore, coinjection of the antagonist peptide significantly inhibited agonist-driven positive selection. Hence, contrary to the prevailing view, positive selection of CD4(+) thymocytes can be induced in vivo by agonist peptides and may be a result of accumulation of signals from TCR engaged by different peptides bound to major histocompatibility complex class II molecules. We have also identified a candidate natural agonist peptide that induces positive selection of CD4(+) TCR transgenic thymocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.