ArticleGenetics2001
C57BL/6J-T-associated sex reversal in mice is caused by reduced expression of a Mus domesticus Sry allele.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Strain-Dependent Functional Variation of a Sex Specific Sox9 Enhancer.Genes to cells : devoted to molecular & cellular mechanisms · 2026Article
- KDM6B is a conserved activator at the top of the male sex determination pathway.Development (Cambridge, England) · 2025Article
- Establishment of an organ culture system to induce Sertoli cell differentiation from undifferentiated mouse gonads.The Journal of veterinary medical science · 2020Article
- Locating and Characterizing a Transgene Integration Site by Nanopore Sequencing.G3 (Bethesda, Md.) · 2019Article
- XY oocytes of sex-reversed females with a Sry mutation deviate from the normal developmental process beyond the mitotic stage†.Biology of reproduction · 2019Article
- Genetic variation in chromosome Y regulates susceptibility to influenza A virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring.Genome biology · 2015Article
- Transgenic expression of Map3k4 rescues T-associated sex reversal (Tas) in mice.Human molecular genetics · 2014Article
- The Y chromosome as a regulatory element shaping immune cell transcriptomes and susceptibility to autoimmune disease.Genome research · 2013Article
- TALEN-mediated editing of the mouse Y chromosome.Nature biotechnology · 2013Article
- Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway.PLoS genetics · 2012Article
- Chromosome y regulates survival following murine coxsackievirus b3 infection.G3 (Bethesda, Md.) · 2012Article
- Mammalian testis-determining factor SRY and the enigma of inherited human sex reversal: frustrated induced fit in a bent protein-DNA complex.The Journal of biological chemistry · 2011Article
- Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination.PLoS biology · 2009Article
- Hermaphrodism and sex reversal associated with the dominant hemimelia mutation in XY mice.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2009Article
- Genetic conflict outweighs heterogametic incompatibility in the mouse hybrid zone?BMC evolutionary biology · 2008Article
- A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation.BMC molecular biology · 2008Article
- SRY and the standoff in sex determination.Molecular endocrinology (Baltimore, Md.) · 2008Review
- Correct dosage of Fog2 and Gata4 transcription factors is critical for fetal testis development in mice.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Meiotic germ cells antagonize mesonephric cell migration and testis cord formation in mouse gonads.Development (Cambridge, England) · 2003Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
C57BL/6J-T-associated sex reversal (B6-TAS) in XY mice results in ovarian development and involves (1) hemizygosity for Tas, a gene located in the region of Chromosome 17 deleted in T(hp) and T(Orl), (2) homozygosity for one or more B6-derived autosomal genes, and (3) the presence of the AKR Y chromosome. Here we report results from experiments designed to investigate the Y chromosome component of this sex reversal. Testis development was restored in B6 T(Orl)/+ XY(AKR) mice carrying a Mus musculus Sry transgene. In addition, two functionally different classes of M. domesticus Sry alleles were identified among eight standard and two wild-derived inbred strains. One class, which includes AKR, did not initiate normal testis development in B6 T(Orl)/+ XY mice, whereas the other did. DNA sequence analysis of the Sry ORF and a 5' 800-bp segment divided these inbred strains into the same groups. Finally, we found that Sry is transcribed in B6 T(Orl)/+ XY(AKR) fetal gonads but at a reduced level. These results pinpoint Sry as the Y-linked component of B6-TAS. We hypothesize that the inability of specific M. domesticus Sry alleles to initiate normal testis development in B6 T(Orl)/+ XY(AKR) mice results from a biologically insufficient level of Sry expression, allowing the ovarian development pathway to proceed.
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