ArticleGenetics2001
Specification of germ cell fates by FOG-3 has been conserved during nematode evolution.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
- Origins of Self-Fertility in ThreeBiology · 2026Review
- Haldane's law works through X:Autosome incompatibility in Caenorhabditis briggsae/C. nigoni hybrids.Nature communications · 2026Article
- TheiScience · 2025Article
- Article
- Rewiring the Sex-Determination Pathway During the Evolution of Self-Fertility.Molecular biology and evolution · 2024Article
- Sex Determination in Nematode Germ Cells.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2022Review
- From "the Worm" to "the Worms" and Back Again: The Evolutionary Developmental Biology of Nematodes.Genetics · 2018Review
- An RNA-Binding Multimer Specifies Nematode Sperm Fate.Cell reports · 2018Article
- Revisiting Suppression of Interspecies Hybrid Male Lethality inG3 (Bethesda, Md.) · 2017Article
- BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes.Nature structural & molecular biology · 2016Article
- Dependence of the sperm/oocyte decision on the nucleosome remodeling factor complex was acquired during recent Caenorhabditis briggsae evolution.Molecular biology and evolution · 2014Article
- Intense sperm-mediated sexual conflict promotes reproductive isolation in Caenorhabditis nematodes.PLoS biology · 2014Article
- The regulation of spermatogenesis and sperm function in nematodes.Seminars in cell & developmental biology · 2014Review
- The evolutionary origins and consequences of self-fertility in nematodes.F1000prime reports · 2014Review
- TRA-1 ChIP-seq reveals regulators of sexual differentiation and multilevel feedback in nematode sex determination.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Evolutionary change within a bipotential switch shaped the sperm/oocyte decision in hermaphroditic nematodes.PLoS genetics · 2013Article
- Independent recruitments of a translational regulator in the evolution of self-fertile nematodes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Insights into species divergence and the evolution of hermaphroditism from fertile interspecies hybrids of Caenorhabditis nematodes.Genetics · 2010Article
- A toolkit for rapid gene mapping in the nematode Caenorhabditis briggsae.BMC genomics · 2010Article
- Chapter 3. Caenorhabditis nematodes as a model for the adaptive evolution of germ cells.Current topics in developmental biology · 2009Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid changes in sexual traits are ubiquitous in evolution. To analyze this phenomenon, we are studying species of the genus Caenorhabditis. These animals use one of two different mating systems-male/hermaphroditic, like the model organism Caenorhabditis elegans, or male/female, like C. remanei. Since hermaphrodites are essentially females that produce sperm for self-fertilization, elucidating the control of cell fate in the germ line in each species could provide the key to understanding how these mating systems evolved. In C. elegans, FOG-3 is required to specify that germ cells become sperm. Thus, we cloned its homologs from both C. remanei and C. briggsae. Each species produces a single homolog of FOG-3, and RNA-mediated interference indicates that FOG-3 functions in each species to specify that germ cells develop as sperm rather than as oocytes. What factors account for the different mating systems? Northern analyses and RT-PCR data reveal that the expression of fog-3 is always correlated with spermatogenesis. Since the promoters for all three fog-3 genes contain binding sites for the transcription factor TRA-1A and are capable of driving expression of fog-3 in C. elegans hermaphrodites, we propose that alterations in the upstream sex-determination pathway, perhaps acting through TRA-1A, allow spermatogenesis in C. elegans and C. briggsae XX larvae but not in C. remanei.
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