ArticleGenetics2001
Changes in mate recognition through alterations of pheromones and receptors in the multisexual mushroom fungus Schizophyllum commune.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 66 citations in OpenAlex.
- Mating-Type System Analysis and Domestication ofJournal of fungi (Basel, Switzerland) · 2026Article
- Evidence for the Existence of Mating Subtypes Within theJournal of fungi (Basel, Switzerland) · 2025Article
- Nuclear-Localized Fluorescent Proteins Enable Visualization of Nuclear Behavior in the BasidiomyceteJournal of fungi (Basel, Switzerland) · 2023Article
- Genome sequencing of Inonotus obliquus reveals insights into candidate genes involved in secondary metabolite biosynthesis.BMC genomics · 2022Article
- Article
- What Role Might Non-Mating Receptors Play inJournal of fungi (Basel, Switzerland) · 2021Article
- Multiple Pathways to Homothallism in Closely Related Yeast Lineages in the Basidiomycota.mBio · 2021Article
- Article
- A genetic linkage map of Pleurotus tuoliensis integrated with physical mapping of the de novo sequenced genome and the mating type loci.BMC genomics · 2018Article
- Activation of the Mating Pheromone Response Pathway ofMycobiology · 2018Article
- Advances in Understanding Mating Type Gene Organization in the Mushroom-Forming FungusG3 (Bethesda, Md.) · 2016Article
- Identification and functional analysis of pheromone and receptor genes in the B3 mating locus of Pleurotus eryngii.PloS one · 2014Article
- Transcriptome and functional analysis of mating in the basidiomycete Schizophyllum commune.Eukaryotic cell · 2012Article
- Interspecific sex in grass smuts and the genetic diversity of their pheromone-receptor system.PLoS genetics · 2011Article
- Evidence for maintenance of sex determinants but not of sexual stages in red yeasts, a group of early diverged basidiomycetes.BMC evolutionary biology · 2011Article
- Fungal mating pheromones: choreographing the dating game.Fungal genetics and biology : FG & B · 2011Review
- Comparative genomics of the mating-type loci of the mushroom Flammulina velutipes reveals widespread synteny and recent inversions.PloS one · 2011Article
- Genome sequence of the model mushroom Schizophyllum commune.Nature biotechnology · 2010Article
- Basidiomycete mating type genes and pheromone signaling.Eukaryotic cell · 2010Review
- In vivo detection of residues required for ligand-selective activation of the S-locus receptor in Arabidopsis.Current biology : CB · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophyllum commune has thousands of mating types defined in part by numerous lipopeptide pheromones and their G-protein-coupled receptors. These molecules are encoded within multiple versions of two redundantly functioning B mating-type loci, B alpha and B beta. Compatible combinations of pheromones and receptors, produced by individuals of different B mating types, trigger a pathway of fertilization required for sexual development. Analysis of the B beta 2 mating-type locus revealed a large cluster of genes encoding a single pheromone receptor and eight different pheromones. Phenotypic effects of mutations within these genes indicated that small changes in both types of molecules could significantly alter their specificity of interaction. For example, a conservative amino acid substitution in a pheromone resulted in a gain of function toward one receptor and a loss of function with another. A two-amino-acid deletion from a receptor precluded the mutant pheromone from activating the mutant receptor, yet this receptor was activated by other pheromones. Sequence comparisons provided clues toward understanding how so many variants of these multigenic loci could have evolved through duplication and mutational divergence. A three-step model for the origin of new variants comparable to those found in nature is presented.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.