ArticleGut2001
Bile reflux gastritis and Barrett's oesophagus: further evidence of a role for duodenogastro-oesophageal reflux?
Article in Gut, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 108 citations in OpenAlex.
- Comparative analysis of endoscopic and nutritional outcomes following distal gastrectomy: Roux-en-Y, uncut Roux-en-Y, and Billroth II with Braun anastomosis.Korean journal of clinical oncology · 2025Article
- A 3-year follow-up study of uncut Roux-en-Y reconstruction: clinical results and outcomes.Surgical endoscopy · 2022Article
- Clinical significance of post-operative bile reflux gastritis.JGH open : an open access journal of gastroenterology and hepatology · 2022Article
- Gastroesophageal Reflux Disease and Foregut Dysmotility in Children with Intestinal Failure.Nutrients · 2020Review
- Intestinal metaplasia around the gastroesophageal junction is frequently associated with antral reactive gastropathy: implications for carcinoma at the gastroesophageal junction.Human pathology · 2020Article
- Article
- Response to TNF-α Is Increasing Along with the Progression in Barrett's Esophagus.Digestive diseases and sciences · 2017Article
- Bile Reflux Scintigraphy After Mini-Gastric Bypass.Obesity surgery · 2017Article
- Cholecystectomy and duodenogastric reflux: interacting effects over the gastric mucosa.SpringerPlus · 2016Article
- Uncut Roux-en-Y Reconstruction after Laparoscopic Distal Gastrectomy Can Be a Favorable Method in Terms of Gastritis, Bile Reflux, and Gastric Residue.Journal of gastric cancer · 2014Article
- Potential mechanism of corpus-predominant gastritis after PPI therapy in Helicobacter pylori-positive patients with GERD.World journal of gastroenterology · 2014Review
- Columnar metaplasia in a surgical mouse model of gastro-esophageal reflux disease is not derived from bone marrow-derived cell.Cancer science · 2013Article
- Intra-operative change of gastric pH during laparotomic cholecystectomy under general anaesthesia: A prospective case-control study.Indian journal of anaesthesia · 2012Article
- MicroRNA-196a & microRNA-101 expression in Barrett's oesophagus in patients with medically and surgically treated gastro-oesophageal reflux.BMC research notes · 2011Article
- The histological and immunohistochemical aspects of bile reflux in patients with gastroesophageal reflux disease.Gastroenterology research and practice · 2011Article
- Gallstones increase the prevalence of Barrett's esophagus.Journal of gastroenterology · 2010Article
- Bile acids induce cdx2 expression through the farnesoid x receptor in gastric epithelial cells.Journal of clinical biochemistry and nutrition · 2010Article
- Expression of bile acid transporting proteins in Barrett's esophagus and esophageal adenocarcinoma.The American journal of gastroenterology · 2009Article
- Bile reflux index after therapeutic biliary procedures.BMC gastroenterology · 2008Article
- Barrett's Esophagus, fundoplication, and cancer.World journal of surgery · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is increasing evidence that reflux of bile plays a part in the pathogenesis of Barrett's oesophagus. Bile injury to the gastric mucosa results in a "chemical" gastritis in which oedema and intestinal metaplasia are prominent.
aimTo determine if patients with Barrett's oesophagus have more bile related changes in antral mucosa than patients with uncomplicated gastro-oesophageal reflux disease (GORD) or non-ulcer dyspepsia (NUD). PATIENTS AND
methodsPatients were identified by a retrospective search of pathology records and those with a clinically confirmed diagnosis of either Barrett's oesophagus or reflux oesophagitis who had oesophageal and gastric biopsies taken at the same endoscopy and had no evidence of Helicobacter pylori infection entered the study. Control biopsies were taken from H pylori negative NUD patients. Antral biopsies were examined "blind" to clinical group and graded for a series of histological features from which the "reflux gastritis score" (RGS) and "bile reflux index" (BRI) could be calculated. The reproducibility of these histological scores was tested by a second pathologist.
resultsThere were 100 patients with Barrett's, 61 with GORD, and 50 with NUD. The RGSs did not differ between groups. BRI values in the Barrett's group were significantly higher than those in GORD subjects (p=0.014) which in turn were higher than those in NUD patients (p=0.037). Similarly, the frequency of high BRI values (>14) was significantly greater in the Barrett's group (29/100; 29%) than in the GORD (9/61; 14.8%) or NUD (4/50; 8%) group. However, agreement on BRI values was "poor", indicating limited applicability of this approach.
conclusionPatients with Barrett's oesophagus have more evidence of bile related gastritis than subjects with uncomplicated GORD or NUD. The presence of bile in the refluxate could be a factor in both the development of "specialised" intestinal metaplasia and malignancy in the oesophagus.
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