ArticleGut2001
Helicobacter pylori infection prevents erosive reflux oesophagitis by decreasing gastric acid secretion.
Article in Gut, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
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Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 202 citations in OpenAlex.
- Risk factors and 26-years worldwide prevalence of endoscopic erosive esophagitis from 1997 to 2022: a meta-analysis.Scientific reports · 2023Pooled it
- Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: systematic review.BMJ (Clinical research ed.) · 2003Pooled it
- Effects of H pylori therapy on erythrocytic and iron parameters in iron deficiency anemia patients with H pylori-positive chronic gastristis.World journal of gastroenterology · 2007Trial
- Medication use and risk of reflux oesophagitis.BMJ open gastroenterology · 2024Article
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- Relationship betweenPrzeglad gastroenterologiczny · 2024Article
- Vitamin C modulates adrenaline-augmented gastric injury via cardiac troponin/creatine kinase pathway in Wistar rats.Iranian journal of basic medical sciences · 2023Article
- Endoscopic findings of cardiac lymphoid hyperplasia andDEN open · 2022Article
- Relationship AmongSisli Etfal Hastanesi tip bulteni · 2022Article
- Potential roles of gastroesophageal reflux in patients with superficial esophageal squamous cell carcinoma without major causative risk factors.Journal of gastroenterology · 2021Article
- Management of Helicobacter pylori infection: The Bhubaneswar Consensus Report of the Indian Society of Gastroenterology.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Article
- Shedding Light on the African Enigma: In Vitro Testing ofMicroorganisms · 2021Article
- Association between Gastroesophageal Reflux Disease and Elastographic Parameters of Liver Steatosis and Fibrosis: Controlled Attenuation Parameter and Liver Stiffness Measurements.Canadian journal of gastroenterology & hepatology · 2021Article
- Endoscopic Prediction for Acid Reflux in Patients without Hiatus Hernia.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2020Article
- Interactions between Helicobacter pylori and gastroesophageal reflux disease.Esophagus : official journal of the Japan Esophageal Society · 2019Review
- Is the incidence of esophageal adenocarcinoma increasing in Japan? Trends from the data of a hospital-based registration system in Akita Prefecture, Japan.Journal of gastroenterology · 2018Article
- Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers.Internal medicine (Tokyo, Japan) · 2017Article
- IsJournal of neurogastroenterology and motility · 2017Review
- Prevalence of cytotoxin-associated genes ofGastroenterology and hepatology from bed to bench · 2017Article
- Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHelicobacter pylori infection is less prevalent and atrophic gastritis is less extensive in patients with reflux oesophagitis than those without it, but few studies have examined this relationship directly.
aimsWe investigated the relationship between H pylori infection, acid secretion, and reflux oesophagitis in Japanese subjects. SUBJECTS: A total of 105 patients with erosive reflux oesophagitis were compared with 105 sex and age matched patients without reflux oesophagitis.
methodsThe diagnosis of H pylori infection was made by histological examination of gastric mucosal biopsy specimens, rapid urease test, and detection of serum IgG antibodies. Acid secretion was assessed by the endoscopic gastrin test.
resultsH pylori infection was present in 36 patients with erosive reflux oesophagitis (34.3%) and in 80 control subjects (76.2%) (odds ratio 0.163, 95% confidence interval 0.09-0.29). Overall acid secretion was significantly greater in patients with reflux oesophagitis. Among H pylori positive patients, acid secretion was greater in patients with reflux oesophagitis than those without oesophagitis.
conclusionIn Japan, erosive reflux oesophagitis occurs most often in the absence of H pylori infection and gastric hyposecretion. Even in the presence of H pylori infection, reflux oesophagitis is more likely to develop in patients without gastric hyposecretion. H pylori infection may inhibit reflux oesophagitis by inducing hypoacidity.
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