ArticleGenes & development2001
The loop domain of heat shock transcription factor 1 dictates DNA-binding specificity and responses to heat stress.
Article in Genes & development, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 80 citations in OpenAlex.
- Article
- Missense mutation of a class B heat shock factor is responsible for the tomato bushy root-2 phenotype.Molecular horticulture · 2022Article
- Heat Shock Proteins and HSF1 in Cancer.Frontiers in oncology · 2022Review
- Structures of heat shock factor trimers bound to DNA.iScience · 2021Article
- Stress-induced transcriptional memory accelerates promoter-proximal pause release and decelerates termination over mitotic divisions.Molecular cell · 2021Article
- HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity.Cells · 2020Review
- A promoter variant in ZNF804A decreasing its expression increases the risk of autism spectrum disorder in the Han Chinese population.Translational psychiatry · 2019Article
- FOXO3 on the Road to Longevity: Lessons From SNPs and Chromatin Hubs.Computational and structural biotechnology journal · 2019Review
- Olfactory experience primes the heat shock transcription factor HSF-1 to enhance the expression of molecular chaperones inScience signaling · 2017Article
- Azadiradione ameliorates polyglutamine expansion disease in Drosophila by potentiating DNA binding activity of heat shock factor 1.Oncotarget · 2016Article
- Purification, crystallization and X-ray diffraction analysis of the DNA-binding domain of human heat-shock factor 2.Acta crystallographica. Section F, Structural biology communications · 2016Article
- Genetic selection for constitutively trimerized human HSF1 mutants identifies a role for coiled-coil motifs in DNA binding.G3 (Bethesda, Md.) · 2013Article
- Genetic variations of HSBP1 gene and its effect on thermal performance traits in Chinese Holstein cattle.Molecular biology reports · 2013Article
- Review
- Inhibition of heat shock transcription factor binding by a linear polyamide binding in an unusual 1:1 mode.Chembiochem : a European journal of chemical biology · 2012Article
- Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast.PloS one · 2011Article
- Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress.Molecular and cellular biology · 2010Article
- A 9 bp cis-element in the promoters of class I small heat shock protein genes on chromosome 3 in rice mediates L-azetidine-2-carboxylic acid and heat shock responses.Journal of experimental botany · 2010Article
- Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli.Molecular biology of the cell · 2009Article
- Hsp70 and cardiac surgery: molecular chaperone and inflammatory regulator with compartmentalized effects.Cell stress & chaperones · 2009Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Eukaryotic heat shock transcription factors (HSF) regulate an evolutionarily conserved stress-response pathway essential for survival against a variety of environmental and developmental stresses. Although the highly similar HSF family members have distinct roles in responding to stress and activating target gene expression, the mechanisms that govern these roles are unknown. Here we identify a loop within the HSF1 DNA-binding domain that dictates HSF isoform specific DNA binding in vitro and preferential target gene activation by HSF family members in both a yeast transcription assay and in mammalian cells. These characteristics of the HSF1 loop region are transposable to HSF2 and sufficient to confer DNA-binding specificity, heat shock inducible HSP gene expression and protection from heat-induced apoptosis in vivo. In addition, the loop suppresses formation of the HSF1 trimer under basal conditions and is required for heat-inducible trimerization in a purified system in vitro, suggesting that this domain is a critical part of the HSF1 heat-stress-sensing mechanism. We propose that this domain defines a signature for HSF1 that constitutes an important determinant for how cells utilize a family of transcription factors to respond to distinct stresses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.