ArticleGenes & development2001
Sequential actions of BMP receptors control neural precursor cell production and fate.
Article in Genes & development, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
108 citing papers in PubMed, 326 citations in OpenAlex.
- Brachiopod genome unveils the evolution of BMP signalling in bilaterian body patterning.Nature communications · 2026Article
- The Principle of Cortical Development and Evolution.Neuroscience bulletin · 2025Review
- TGFβ family signaling in human stem cell self-renewal and differentiation.Cell regeneration (London, England) · 2024Review
- BMP7 expression in mammalian cortical radial glial cells increases the length of the neurogenic period.Protein & cell · 2024Article
- Assessment of the level of apoptosis in differentiated pseudo-neuronal cells derived from neural stem cells under the influence of various inducers.American journal of stem cells · 2024Review
- Chromosome 1p status in neuroblastoma correlates with higher expression levels of miRNAs targeting neuronal differentiation pathway.In vitro cellular & developmental biology. Animal · 2023Article
- Regulation of choroid plexus development and its functions.Cellular and molecular life sciences : CMLS · 2022Review
- Ligand-receptor promiscuity enables cellular addressing.Cell systems · 2022Article
- The context-dependent, combinatorial logic of BMP signaling.Cell systems · 2022Article
- Overexpression of bone morphogenetic protein 7 reduces oligodendrocytes loss and promotes functional recovery after spinal cord injury.Journal of cellular and molecular medicine · 2021Article
- Getting in touch with your senses: Mechanisms specifying sensory interneurons in the dorsal spinal cord.WIREs mechanisms of disease · 2021Review
- Single cell RNA sequencing detects persistent cell type- and methylmercury exposure paradigm-specific effects in a human cortical neurodevelopmental model.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021Article
- Dorsal commissural axon guidance in the developing spinal cord.Current topics in developmental biology · 2021Review
- BuMPing Into Neurogenesis: How the Canonical BMP Pathway Regulates Neural Stem Cell Divisions Throughout Space and Time.Frontiers in neuroscience · 2021Review
- Mendelian randomization and experimental IUGR reveal the adverse effect of low birth weight on lung structure and function.Scientific reports · 2020Article
- The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon.Nature communications · 2020Article
- Exploiting the Complexities of Glioblastoma Stem Cells: Insights for Cancer Initiation and Therapeutic Targeting.International journal of molecular sciences · 2020Review
- Extracellular Control of Radial Glia Proliferation and Scaffolding During Cortical Development and Pathology.Frontiers in cell and developmental biology · 2020Review
- Palmitoylation of BMPR1a regulates neural stem cell fate.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death.Scientific reports · 2019Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone morphogenetic proteins (BMPs) have diverse and sometimes paradoxical effects during embryonic development. To determine the mechanisms underlying BMP actions, we analyzed the expression and function of two BMP receptors, BMPR-IA and BMPR-IB, in neural precursor cells in vitro and in vivo. Neural precursor cells always express Bmpr-1a, but Bmpr-1b is not expressed until embryonic day 9 and is restricted to the dorsal neural tube surrounding the source of BMP ligands. BMPR-IA activation induces (and Sonic hedgehog prevents) expression of Bmpr-1b along with dorsal identity genes in precursor cells and promotes their proliferation. When BMPR-IB is activated, it limits precursor cell numbers by causing mitotic arrest. This results in apoptosis in early gestation embryos and terminal differentiation in mid-gestation embryos. Thus, BMP actions are first inducing (through BMPR-IA) and then terminating (through BMPR-IB), based on the accumulation of BMPR-IB relative to BMPR-IA. We describe a feed-forward mechanism to explain how the sequential actions of these receptors control the production and fate of dorsal precursor cells from neural stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.