ArticleMolecular and cellular biology2001
Xenopus U3 snoRNA GAC-Box A' and Box A sequences play distinct functional roles in rRNA processing.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- Biallelic variants in the conserved ribosomal protein chaperone geneProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Synergistic defects in pre-rRNA processing from mutations in the U3-specific protein Rrp9 and U3 snoRNA.Nucleic acids research · 2020Article
- Maturation of the 90S pre-ribosome requires Mrd1 dependent U3 snoRNA and 35S pre-rRNA structural rearrangements.Nucleic acids research · 2018Article
- Implication of the box C/D snoRNP assembly factor Rsa1p in U3 snoRNP assembly.Nucleic acids research · 2017Article
- C/D-box snoRNAs form methylating and non-methylating ribonucleoprotein complexes: Old dogs show new tricks.BioEssays : news and reviews in molecular, cellular and developmental biology · 2017Review
- The path from student to mentor and from chromosomes to replication to genomics.Molecular biology of the cell · 2016Article
- The human box C/D snoRNAs U3 and U8 are required for pre-rRNA processing and tumorigenesis.Oncotarget · 2016Article
- The ribosome biogenesis factor Nol11 is required for optimal rDNA transcription and craniofacial development in Xenopus.PLoS genetics · 2015Article
- hUTP24 is essential for processing of the human rRNA precursor at site A1, but not at site A0.RNA biology · 2015Article
- Review
- Ribonucleoproteins in archaeal pre-rRNA processing and modification.Archaea (Vancouver, B.C.) · 2013Review
- A second base pair interaction between U3 small nucleolar RNA and the 5'-ETS region is required for early cleavage of the yeast pre-ribosomal RNA.Nucleic acids research · 2011Article
- Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits.The Journal of cell biology · 2010Article
- Strong dependence between functional domains in a dual-function snoRNA infers coupling of rRNA processing and modification events.Nucleic acids research · 2010Article
- U3 snoRNA genes are multi-copy and frequently linked to U5 snRNA genes in Euglena gracilis.BMC genomics · 2009Article
- The 5' external transcribed spacer in mouse ribosomal RNA contains two cleavage sites.RNA (New York, N.Y.) · 2009Article
- Analysis of sequence and structural features that identify the B/C motif of U3 small nucleolar RNA as the recognition site for the Snu13p-Rrp9p protein pair.Molecular and cellular biology · 2007Article
- Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammalian cells.The EMBO journal · 2005Article
- An evolutionary intra-molecular shift in the preferred U3 snoRNA binding site on pre-ribosomal RNA.Nucleic acids research · 2005Article
- Role of pre-rRNA base pairing and 80S complex formation in subnucleolar localization of the U3 snoRNP.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mutations in the 5' portion of Xenopus U3 snoRNA were tested for function in oocytes. The results revealed a new cleavage site (A0) in the 3' region of vertebrate external transcribed spacer sequences. In addition, U3 mutagenesis uncoupled cleavage at sites 1 and 2, flanking the 5' and 3' ends of 18S rRNA, and generated novel intermediates: 19S and 18.5S pre-rRNAs. Furthermore, specific nucleotides in Xenopus U3 snoRNA that are required for cleavages in pre-rRNA were identified: box A is essential for site A0 cleavage, the GAC-box A' region is necessary for site 1 cleavage, and the 3' end of box A' and flanking nucleotides are required for site 2 cleavage. Differences between metazoan and yeast U3 snoRNA-mediated rRNA processing are enumerated. The data support a model where metazoan U3 snoRNA acts as a bridge to draw together the 5' and 3' ends of the 18S rRNA coding region within pre-rRNA to coordinate their cleavage.
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Registered trials
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