ArticleCell2001
A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders.
Article in Cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 216 citations in OpenAlex.
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- Validation of the neuroconnective endophenotype questionnaire (NEQ): a new clinical tool for medicine and psychiatry resulting from the contribution of Ehlers-Danlos syndrome.Frontiers in medicine · 2023Article
- Low- and high-anxious hypermobile Ehlers-Danlos syndrome patients: comparison of psychosocial and health variables.Rheumatology international · 2018Observational
- Infralimbic Neurotrophin-3 Infusion Rescues Fear Extinction Impairment in a Mouse Model of Pathological Fear.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Impairment of Working Memory, Decision-making, and Executive Function in the First-Degree Relatives of People with Panic Disorder: A Pilot Study.Frontiers in psychiatry · 2017Article
- Psychiatric disorders in Ehlers-Danlos syndrome are frequent, diverse and strongly associated with pain.Rheumatology international · 2016Article
- Genomic structural variation in affective, anxiety, and stress-related disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2015Review
- Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Protein tyrosine phosphatases PTPδ, PTPσ, and LAR: presynaptic hubs for synapse organization.Trends in neurosciences · 2013Review
- Hypermobility in dance: asset, not liability.Clinical rheumatology · 2013Review
- Joint hypermobility syndrome: problems that require psychological intervention.Rheumatology international · 2011Review
- Joint hypermobility and anxiety: the state of the art.Current psychiatry reports · 2011Review
- Controlled somatic and germline copy number variation in the mouse model.Current genomics · 2010Article
- Association between reduced copy-number at T-cell receptor gamma (TCRgamma) and childhood allergic asthma: A possible role for somatic mosaicism.Mutation research · 2010Article
- Advances in molecular genetics of panic disorder.Molecular psychiatry · 2010Review
- An alternative approach to medical genetics based on modern evolutionary biology. Part 5: epigenetics and genomics.Journal of the Royal Society of Medicine · 2009Review
- Joint hypermobility syndrome pain.Current pain and headache reports · 2009Review
- The long (and winding) road to gene discovery for canine hip dysplasia.Veterinary journal (London, England : 1997) · 2009Review
- Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles.American journal of human genetics · 2008Article
- Quantitative trait loci for hip dysplasia in a cross-breed canine pedigree.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anxiety disorders are complex and common psychiatric illnesses associated with considerable morbidity and social cost. We have studied the molecular basis of the cooccurrence of panic and phobic disorders with joint laxity. We have identified an interstitial duplication of human chromosome 15q24-26 (named DUP25), which is significantly associated with panic/agoraphobia/social phobia/joint laxity in families, and with panic disorder in nonfamilial cases. Mosaicism, different forms of DUP25 within the same family, and absence of segregation of 15q24-26 markers with DUP25 and the psychiatric phenotypes suggest a non-Mendelian mechanism of disease-causing mutation. We propose that DUP25, which is present in 7% control subjects, is a susceptibility factor for a clinical phenotype that includes panic and phobic disorders and joint laxity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.