ArticleDigestive diseases and sciences2001
Coordinated Muc2 and Muc3 mucin gene expression in Trichinella spiralis infection in wild-type and cytokine-deficient mice.
Article in Digestive diseases and sciences, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Lactic Acid Bacteria Surface Proteins in the Mechanisms of Cell Adhesion and Immunoregulation.Food science & nutrition · 2024Article
- A Small Intestinal Helminth Infection Alters Colonic Mucus and Shapes the Colonic Mucus Microbiome.International journal of molecular sciences · 2024Article
- Production of Intestinal Mucins, sIgA, and Metallothionein after Administration of Zinc and Infection ofLife (Basel, Switzerland) · 2022Article
- Tissue-specific immunity in helminth infections.Mucosal immunology · 2022Review
- Lentinan -triggered butyrate-producing bacteria drive the expulsion of the intestinal helminthFrontiers in immunology · 2022Article
- Comparative expression profiles of host circulating miRNAs in response to Trichinella spiralis infection.Veterinary research · 2020Article
- A sticky end for gastrointestinal helminths; the role of the mucus barrier.Parasite immunology · 2018Review
- Goblet cells and mucins: role in innate defense in enteric infections.Pathogens (Basel, Switzerland) · 2013Review
- IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection.PLoS pathogens · 2013Article
- Helminthic therapy: improving mucosal barrier function.Trends in parasitology · 2012Review
- γδ T cells play a protective role during infection with Nippostrongylus brasiliensis by promoting goblet cell function in the small intestine.Immunology · 2011Article
- Muc17 protects intestinal epithelial cells from enteroinvasive E. coli infection by promoting epithelial barrier integrity.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Tumor necrosis factor-α and Muc2 mucin play major roles in disease onset and progression in dextran sodium sulphate-induced colitis.PloS one · 2011Article
- Stromal IFN-γR-signaling modulates goblet cell function during Salmonella Typhimurium infection.PloS one · 2011Article
- Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection.Gastroenterology · 2010Article
- Characterisation of effector mechanisms at the host:parasite interface during the immune response to tissue-dwelling intestinal nematode parasites.International journal for parasitology · 2009Review
- Expression profiling reveals novel innate and inflammatory responses in the jejunal epithelial compartment during infection with Trichinella spiralis.Infection and immunity · 2004Article
- Expression of mucins in mucoid otitis media.Journal of the Association for Research in Otolaryngology : JARO · 2003Article
- Mammalian gut immunity.Biomedical journalReview
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mucin hypersecretion is an important component of the immune response to gastrointestinal nematode infection. Two discrete types of mucin proteins exist in the mouse intestine, secretory Muc2 and membrane-bound Muc3. We examined Muc2 and Muc3 expression in wild-type mice and mice lacking gamma interferon receptor (IFNgammaR-/-), tumor necrosis factor receptor 1 (TNFR1-/-) and interleukin 4 (IL4-/-) infected with Trichinella spiralis. Infected wild-type mice demonstrated significant goblet cell hyperplasia and increased mucin glycoprotein. In situ hybridization showed this was accompanied by increases in Muc2 and Muc3 mRNA. Total intestinal mucin protein and Muc2 and Muc3 mRNA levels were also significantly increased in cytokine-deficient mice. These data demonstrate the coordinated up-regulation of two types of mucin genes in response to T. spiralis infection and may form the basis of an innate mucosal response independent of IFN-gamma, TNF, and IL-4.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.