ReviewDiabetologia2001
The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes.
Review in Diabetologia, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 205 papers, 5 of them syntheses that pooled it.
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Who cites it
205 citing papers in PubMed, 5 syntheses or guidelines pooled it, 617 citations in OpenAlex.
- Clinical parameters and emerging biomarkers of partial remission in pediatric type 1 diabetes: a systematic review.Frontiers in endocrinology · 2026Pooled it
- Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach.Nature communications · 2022Pooled it
- Double or hybrid diabetes: A systematic review on disease prevalence, characteristics and risk factors.Nutrition & diabetes · 2019Pooled it
- Type 2 Diabetes: How Much of an Autoimmune Disease?Frontiers in endocrinology · 2019Pooled it
- Overweight and obesity in youth with type 1 diabetes.Annual review of nursing research · 2013Pooled it
- Increasing plasma glucose before the development of type 1 diabetes-the TRIGR study.Pediatric diabetes · 2021Trial
- Clinical and Metabolic Characteristics among Mexican Children with Different Types of Diabetes Mellitus.PloS one · 2016Trial
- Physical Activity, Blood Glucose and C-Peptide in Healthy School-Children, a Longitudinal Study.PloS one · 2016Trial
- Pre-type 1 diabetes dysmetabolism: maximal sensitivity achieved with both oral and intravenous glucose tolerance testing.The Journal of pediatrics · 2007Trial
- Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study.Diabetologia · 2005Trial
- Lifestyle and environmental risk factors for adult-onset autoimmune diabetes: current evidence and future directions.Diabetologia · 2026Review
- Type 1 Diabetes Mellitus as a Model of Body Composition Transformation: Pathogenetic Unity of Combined Phenotypes.International journal of molecular sciences · 2026Review
- Increasing incidence of type 1 diabetes in children and adolescents from 2012 to 2021 in Germany: trends before and during the COVID-19 pandemic.European journal of epidemiology · 2026Article
- Article
- Increased Incidence of Type 1 Diabetes and Co-Existing Thyroid Autoimmunity During the COVID-19 Pandemic in Sweden.Acta paediatrica (Oslo, Norway : 1992) · 2026Observational
- Obesity in Type 1 Diabetes: Moving Beyond the "Lean" Disease Paradigm to Understand Risk, Complications, and Treatment.Current obesity reports · 2026Review
- The inflammatory path toward type 1 diabetes begins during pregnancy.Nature communications · 2026Article
- Prevalence and characteristics of overweight/obesity in children newly diagnosed with type 1 diabetes in Kuwait.Frontiers in endocrinology · 2026Article
- Smoking, GAD65 autoimmunity, genetic susceptibility to type 1 diabetes and incident adult-onset diabetes in the EPIC-InterAct case-cohort study.Metabologia · 2026Article
- Managing Obesity in Individuals with Cardiovascular Disease: Are We Missing the Obvious?European cardiology · 2026Review
145 more citing papers are in PubMed but not listed here.
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood glucose concentrations are controlled by a loop incorporating two components, the beta cells which secrete insulin and the insulin-sensitive tissues (liver, muscle, adipose) which respond to it. Loss of blood glucose control might result from failure of the beta cells to secrete insulin, resistance of the tissues to its action, or a combination of both. The distinctions between Type I (insulin-dependent) and Type II (non-insulin-dependent) diabetes mellitus are becoming increasingly blurred both clinically and aetiologically, where beta-cell insufficiency is the shared characteristic. The 'Accelerator Hypothesis' identifies three processes which variably accelerate the loss of beta cells through apoptosis: constitution, insulin resistance and autoimmunity. None of the accelerators leads to diabetes without excess weight gain, a trend which the 'Accelerator Hypothesis' deems central to the rising incidence of both types of diabetes in the industrially developed world. Weight gain causes an increase in insulin resistance, which results in the weakening of glucose control. The rising blood glucose (glucotoxicity) accelerates beta-cell apoptosis directly in all and, by inducing beta-cell immunogens, further accelerates it in a subset genetically predisposed to autoimmunity. Rather than overlap between two types of diabetes, the 'Accelerator Hypothesis' envisages overlay. Body mass is central to the development and rising incidence of all diabetes. Only tempo distinguishes the 'types'. The control of weight gain, and with it insulin resistance, could be the means of minimising both.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.