ArticleAmerican journal of human genetics2001
Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families.
Article in American journal of human genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 263 citations in OpenAlex.
- Association between E469K polymorphism in the ICAM1 gene and the risk of diabetic nephropathy: a meta-analysis.Lipids in health and disease · 2018Pooled it
- Type 1 diabetes in a Nigerian family - occurrence in three out of four siblings: A case report.World journal of diabetes · 2019Article
- Type 1 diabetes genome-wide association studies: not to be lost in translation.Clinical & translational immunology · 2017Review
- Type 1 diabetes genetic susceptibility and dendritic cell function: potential targets for treatment.Journal of leukocyte biology · 2016Review
- Article
- Variants in PTPN22 and SMOC2 genes and the risk of thyroid disease in the Jordanian Arab population.Endocrine · 2013Article
- Risk factors and primary prevention trials for type 1 diabetes.International journal of biological sciences · 2013Review
- Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes.Diabetes · 2010Article
- Association of single nucleotide polymorphisms in cytotoxic T-lymphocyte antigen 4 and susceptibility to autoimmune type 1 diabetes in Tunisians.Clinical and vaccine immunology : CVI · 2010Article
- Genetics of type 1 diabetes: what's next?Diabetes · 2010Review
- Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8.The Journal of investigative dermatology · 2010Article
- HLA genotyping in the international Type 1 Diabetes Genetics Consortium.Clinical trials (London, England) · 2010Article
- Approaches in type 1 diabetes research: A status report.International journal of diabetes in developing countries · 2009Article
- Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium.Diabetes · 2009Article
- Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms.Endocrine reviews · 2008Review
- Insulin gene polymorphisms in type 1 diabetes, Addison's disease and the polyglandular autoimmune syndrome type II.BMC medical genetics · 2008Article
- Evaluation of the association between the common E469K polymorphism in the ICAM-1 gene and diabetic nephropathy among type 1 diabetic patients in GoKinD population.BMC medical genetics · 2008Article
- Genetic loci linked to type 1 diabetes and multiple sclerosis families in Sardinia.BMC medical genetics · 2008Article
- Posttranslational Protein Modifications in Type 1 Diabetes - Genetic Studies with PCMT1, the Repair Enzyme Protein Isoaspartate Methyltransferase (PIMT) Encoding Gene.The review of diabetic studies : RDS · 2008Article
- Genetics of autoimmune diabetes mellitus.Wiener medizinische Wochenschrift (1946) · 2008Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Type 1 diabetes (T1D) is a genetically complex disorder of glucose homeostasis that results from the autoimmune destruction of the insulin-secreting cells of the pancreas. Two previous whole-genome scans for linkage to T1D in 187 and 356 families containing affected sib pairs (ASPs) yielded apparently conflicting results, despite partial overlap in the families analyzed. However, each of these studies individually lacked power to detect loci with locus-specific disease prevalence/sib-risk ratios (lambda(s)) <1.4. In the present study, a third genome scan was performed using a new collection of 225 multiplex families with T1D, and the data from all three of these genome scans were merged and analyzed jointly. The combined sample of 831 ASPs, all with both parents genotyped, provided 90% power to detect linkage for loci with lambda(s) = 1.3 at P=7.4x10(-4). Three chromosome regions were identified that showed significant evidence of linkage (P<2.2x10(-5); LOD scores >4), 6p21 (IDDM1), 11p15 (IDDM2), 16q22-q24, and four more that showed suggestive evidence (P<7.4x10(-4), LOD scores > or =2.2), 10p11 (IDDM10), 2q31 (IDDM7, IDDM12, and IDDM13), 6q21 (IDDM15), and 1q42. Exploratory analyses, taking into account the presence of specific high-risk HLA genotypes or affected sibs' ages at disease onset, provided evidence of linkage at several additional sites, including the putative IDDM8 locus on chromosome 6q27. Our results indicate that much of the difficulty in mapping T1D susceptibility genes results from inadequate sample sizes, and the results point to the value of future international collaborations to assemble and analyze much larger data sets for linkage in complex diseases.
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