ArticleJournal of virology2001
Peptides corresponding to the heptad repeat motifs in the transmembrane protein (gp41) of human immunodeficiency virus type 1 elicit antibodies to receptor-activated conformations of the envelope glycoprotein.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- Utilizing Machine Learning to Improve Neutralization Potency of an HIV-1 Antibody Targeting the gp41 N-Heptad Repeat.ACS chemical biology · 2025Article
- A Derivative of the D5 Monoclonal Antibody That Targets the gp41 N-Heptad Repeat of HIV-1 with Broad Tier-2-Neutralizing Activity.Journal of virology · 2021Article
- The high-affinity immunoglobulin receptor FcγRI potentiates HIV-1 neutralization via antibodies against the gp41 N-heptad repeat.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- HIV-1 gp41 Residues Modulate CD4-Induced Conformational Changes in the Envelope Glycoprotein and Evolution of a Relaxed Conformation of gp120.Journal of virology · 2018Article
- Nonneutralizing Antibodies Induced by the HIV-1 gp41 NHR Domain Gain Neutralizing Activity in the Presence of the HIV Fusion Inhibitor Enfuvirtide: a Potential Therapeutic Vaccine Strategy.Journal of virology · 2015Article
- A novel gene therapy strategy using secreted multifunctional anti-HIV proteins to confer protection to gene-modified and unmodified target cells.Gene therapy · 2014Article
- Elevated temperature triggers human respiratory syncytial virus F protein six-helix bundle formation.Virology · 2010Article
- ADS-J1 inhibits human immunodeficiency virus type 1 entry by interacting with the gp41 pocket region and blocking fusion-active gp41 core formation.Antimicrobial agents and chemotherapy · 2009Article
- Conformational changes in HIV-1 gp41 in the course of HIV-1 envelope glycoprotein-mediated fusion and inactivation.Biochemistry · 2005Article
- The C terminus of the B5 receptor for herpes simplex virus contains a functional region important for infection.Journal of virology · 2005Article
- Binding of the 2F5 monoclonal antibody to native and fusion-intermediate forms of human immunodeficiency virus type 1 gp41: implications for fusion-inducing conformational changes.Journal of virology · 2004Article
- Regulation of human immunodeficiency virus type 1 Env-mediated membrane fusion by viral protease activity.Journal of virology · 2004Article
- Protein grafting of an HIV-1-inhibiting epitope.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Variable sensitivity to substitutions in the N-terminal heptad repeat of Mason-Pfizer monkey virus transmembrane protein.Journal of virology · 2003Article
- Direct evidence that C-peptide inhibitors of human immunodeficiency virus type 1 entry bind to the gp41 N-helical domain in receptor-activated viral envelope.Journal of virology · 2003Article
- Redox-triggered infection by disulfide-shackled human immunodeficiency virus type 1 pseudovirions.Journal of virology · 2003Article
- HIV-1 envelope proteins complete their folding into six-helix bundles immediately after fusion pore formation.Molecular biology of the cell · 2003Article
- Peptides trap the human immunodeficiency virus type 1 envelope glycoprotein fusion intermediate at two sites.Journal of virology · 2003Article
- Antigenic properties of the human immunodeficiency virus transmembrane glycoprotein during cell-cell fusion.Journal of virology · 2002Article
- Dissection of human immunodeficiency virus type 1 entry with neutralizing antibodies to gp41 fusion intermediates.Journal of virology · 2002Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Two heptad repeat regions in the ectodomain of the human immunodeficiency virus type 1 (HIV-1) transmembrane subunit (gp41) self-assemble into a six-helix bundle structure that is critical for virus entry. Immunizations with peptides corresponding to these regions generated antibodies specific to the receptor-activated conformations of gp41.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.