ArticleJournal of the American Society for Mass Spectrometry2001
Targeted use of exoglycosidase digestion for the structural elucidation of neutral O-linked oligosaccharides.
Article in Journal of the American Society for Mass Spectrometry, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Rapid Screening of Bovine Milk Oligosaccharides in a Whey Permeate Product and Domestic Animal Milks by Accurate Mass Database and Tandem Mass Spectral Library.Journal of agricultural and food chemistry · 2016Article
- In-depth method for the characterization of glycosylation in manufactured recombinant monoclonal antibody drugs.Analytical chemistry · 2014Article
- Annotation and structural elucidation of bovine milk oligosaccharides and determination of novel fucosylated structures.Glycobiology · 2013Article
- Structural Identification of O-Linked Oligosaccharides Using Exoglycosidases and MSn Together with UniCarb-DB Fragment Spectra Comparison.Metabolites · 2012Article
- Structure determination by MALDI-IRMPD mass spectrometry and exoglycosidase digestions of O-linked oligosaccharides from Xenopus borealis egg jelly.Glycobiology · 2011Article
- Annotation and structural analysis of sialylated human milk oligosaccharides.Journal of proteome research · 2011Article
- Development of an annotated library of neutral human milk oligosaccharides.Journal of proteome research · 2010Article
- Structural analysis of sulfated glycans by sequential double-permethylation using methyl iodide and deuteromethyl iodide.Journal of the American Society for Mass Spectrometry · 2009Article
- Oligosaccharide analysis using anion attachment in negative mode electrospray mass spectrometry.Journal of the American Society for Mass Spectrometry · 2005Article
- Mass spectrometric strategy for the characterization of lipooligosaccharides from Neisseria gonorrhoeae 302 using FTICR.Journal of the American Society for Mass Spectrometry · 2002Article
- Evidence for long-range glycosyl transfer reactions in the gas phase.Journal of the American Society for Mass Spectrometry · 2002Article
- Profiling with structural elucidation of the neutral and anionic O-linked oligosaccharides in the egg jelly coat of Xenopus laevis by Fourier transform mass spectrometry.Glycoconjugate journal · 2001Article
- Carlito B. Lebrilla: Building Instruments, Fields and Opportunities From the Ground up.Mass spectrometry reviewsArticle
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Authors and funding
4 authors.
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Abstract
Exoglycosidase digestion in combination with the catalog-library approach (CLA) is used with matrix-assisted laser desorption/ionization Fourier transform mass spectrometry (MALDI-FTMS) to obtain the complete structure of oligosaccharides. The CLA is a collision-induced dissociation (CID)-based method used to determine the structure of O-linked neutral oligosaccharides. It provides both linkage and stereochemical information. Exoglycosidases are used to confirm independently the validity of the CLA. In some cases, the CLA provides structural information on all but a single residue. Exoglycosidase is used to refine these structures. In this way, exoglycosidase use is targeted employing only a small number of enzymes. Exoglycosidase arrays, which have been used with N-linked oligosaccharides, is avoided despite the larger variations in structures of O-linked species.
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