Evidence map›Paper›PMID 11506196›Full record

Trial reportJournal of clinical immunology2001

Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes.

H S Gill, K J Rutherfurd, M L Cross

2 registry-linked trialsAbstract readClinical TrialControlled Clinical Trial
PubMed Publisher
In one paragraph

Trial report in Journal of clinical immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 79 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 3 pooled it
19.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07439978 phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Physiological Study of a Fermented Yogurt Drink Containing Probiotics

TypeinterventionalSponsorUniversity College DublinRan2026 to 2026Enrolled50ConditionsColonization, Asymptomatic, ColonisationArmsprobiotic containing L.rhamnosus R0011 strain, 200 ml yogurt drink
NCT07510282 phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Physiological Study on How Probiotic Delivered to the Small Intestine Changes Microbiota

TypeinterventionalSponsorUniversity College DublinRan2026 to 2026Enrolled25ConditionsColonization, Asymptomatic, ColonizationArmsProbiotic containing L.rhamnosus R0011 strain, 200 ml yogurt drink
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 3 syntheses or guidelines pooled it, 304 citations in OpenAlex.

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  4. Effect of Heat-TreatedNutrients · 2024
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

H S GillMilk & Health Research Centre, Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand. H.S.Gill@massey.ac.nz
K J Rutherfurd
M L Cross
Massey University · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many elderly subjects are at increased risk of infectious and noninfectious diseases due to an age-related decline in lymphoid cell activity (immunosenescence). Noninvasive means of enhancing cellular immunity are therefore desirable in the elderly. Previous reports have suggested that dietary supplementation could represent an effective means of enhancing the activity of circulating natural killer (NK) cells in the elderly. In the present study, we have conducted a pre-post intervention trial to determine the impact of dietary supplementation with probiotic lactic acid bacteria (LAB) on peripheral blood NK cell activity in healthy elderly subjects. Twenty-seven volunteers consumed low-fat/low-lactose milk supplemented with known immunostimulatory LAB strains (Lactobacillus rhamnosus HN001 or Bifidobacterium lactis HN019) for a period of 3 weeks. A dietary run-in of milk alone was shown to have no significant effect on NK cells. In contrast, the proportion of CD56-positive lymphocytes in peripheral circulation was higher following consumption of either LAB strain, and ex vivo PBMC tumoricidal activity against K562 cells was also increased. Supplementation with HN001 or HN019 increased tumoricidal activity by an average of 101 and 62%, respectively; these increases were significantly correlated with age, with subjects older than 70 years experiencing significantly greater improvements than those under 70 years. These results demonstrate that dietary consumption of probiotic LAB in a milk-based diet may offer benefit to elderly consumers to combat some of the deleterious effects of immunosenescence on cellular immunity.

Indexed as

AgedAged, 80 and overAgingBifidobacteriumCytotoxicity, ImmunologicFemaleHumansImmunity, CellularIn Vitro TechniquesK562 CellsKiller Cells, NaturalLactobacillusMaleMiddle AgedProbiotics

Identifiers

PMID11506196
OpenAlexW1522937979

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.