ArticleMolecular and cellular biochemistry2001
Activation of multiple MAPK pathways (ERKs, JNKs, p38-MAPK) by diverse stimuli in the amphibian heart.
Article in Molecular and cellular biochemistry, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 32 citations in OpenAlex.
- Organophosphate pesticides and new-onset diabetes mellitus: From molecular mechanisms to a possible therapeutic perspective.World journal of diabetes · 2021Review
- Organophosphorus Compounds and MAPK Signaling Pathways.International journal of molecular sciences · 2020Review
- Beyond the Mammalian Heart: Fish and Amphibians as a Model for Cardiac Repair and Regeneration.Journal of developmental biology · 2015Review
- Hyperosmotic stress-induced corneal epithelial cell death through activation of Polo-like kinase 3 and c-Jun.Investigative ophthalmology & visual science · 2011Article
- Catestatin (chromogranin A344-364) is a novel cardiosuppressive agent: inhibition of isoproterenol and endothelin signaling in the frog heart.American journal of physiology. Heart and circulatory physiology · 2008Article
- Effects of various oxidants and antioxidants on the p38-MAPK signalling pathway in the perfused amphibian heart.Molecular and cellular biochemistry · 2006Article
- Various stressors rapidly activate the p38-MAPK signaling pathway in Mytilus galloprovincialis (Lam.).Molecular and cellular biochemistry · 2004Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the expression and activation of three MAPK subfamilies in the isolated perfused amphibian heart. ERK was detected as a 43 kDa band; p38-MAPK was detected as a band corresponding to 38 kDa and JNKs were detected as two bands corresponding to 46 and 52 kDa, respectively. PMA induced the activation of the ERK pathway as assessed by determining the phosphorylation state of ERK and the upstream component MEK1/2. PD98059 abolished this activation. p38-MAPK was phosphorylated by sorbitol (almost 12-fold, maximal within 10-15 min) and JNKs were phosphorylated and activated by sorbitol or anoxia/reoxygenation (approximately 4- and 2.5-fold, respectively). SB203580 completely blocked the activation of p38-MAPK by sorbitol. These results indicate that the MAPK pathways activated by phorbol esters, hyperosmotic stress or anoxia/ reoxygenation in the amphibian heart may have an important role in this experimental system.
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