ArticleMolecular and cellular biochemistry2001
Induction of cardiac FABP gene expression by long chain fatty acids in cultured rat muscle cells.
Article in Molecular and cellular biochemistry, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Successful reduction of inflammatory responses and arachidonic acid-cyclooxygenase 2 pathway in human pulmonary artery endothelial cells by silencing adipocyte fatty acid-binding protein.Journal of inflammation (London, England) · 2017Article
- Fatty acid-dependent expression of the muscle FABP gene - comparative analysis of gene control in functionally related, but evolutionary distant animal systems.Molecular and cellular biochemistry · 2007Article
- Characterization of a new fatty acid response element that controls the expression of the locust muscle FABP gene.Molecular and cellular biochemistry · 2002Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The induction of cardiac FABP expression by long-chain fatty acids was measured in cultured rat myoblasts, myotubes and adult cardiomyocytes. With quantitative RT-PCR techniques, the primary transcription product of the FABP gene and the mature mRNA were measured. Incubations of 30 min resulted in a larger than 2-fold increase of the primary transcript in all cells, and FABP mRNA more than doubled in myoblasts and cardiomyocytes after 10 h of fatty acid exposure. The results demonstrate that long chain fatty acids induce the expression of the cardiac FABP gene in muscle cells and their undifferentiated precursors at the level of transcription initiation, suggesting that all factors involved in fatty acid dependent gene induction are already present in myoblasts. Thus, myoblast cell lines should be useful for the characterization of fatty acid response elements that control the expression of the FABP gene.
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