ArticleProceedings of the National Academy of Sciences of the United States of America2001
Self-organization of a radial microtubule array by dynein-dependent nucleation of microtubules.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 85 citations in OpenAlex.
- Branched microtubule nucleation and dynein transport organize RanGTP asters inMolecular biology of the cell · 2024Article
- Morphological and cytoskeleton changes in cells after EMT.Scientific reports · 2023Article
- Multiple asters organize the yolk microtubule network during dclk2-GFP zebrafish epiboly.Scientific reports · 2022Article
- Article
- Self-Organization of Cellular Units.Annual review of cell and developmental biology · 2021Review
- Persistent growth of microtubules at low density.Molecular biology of the cell · 2021Article
- Tuning mitochondrial structure and function to criticality by fluctuation-driven mechanotransduction.Scientific reports · 2020Article
- Dynamic microtubules drive fibroblast spreading.Biology open · 2018Article
- Microtubules and Microtubule-Associated Proteins.Cold Spring Harbor perspectives in biology · 2018Review
- Single microtubules and small networks become significantly stiffer on short time-scales upon mechanical stimulation.Scientific reports · 2017Article
- Stimulation of microtubule-based transport by nucleation of microtubules on pigment granules.Molecular biology of the cell · 2017Article
- Interaction of microtubules with the actin cytoskeleton via cross-talk of EB1-containing +TIPs and γ-actin in epithelial cells.Oncotarget · 2016Article
- Tracking of plus-ends reveals microtubule functional diversity in different cell types.Scientific reports · 2016Article
- Motor-mediated cortical versus astral microtubule organization in lipid-monolayered droplets.The Journal of biological chemistry · 2014Article
- Stimulation of the CLIP-170--dependent capture of membrane organelles by microtubules through fine tuning of microtubule assembly dynamics.Molecular biology of the cell · 2011Article
- Orientation and function of the nuclear-centrosomal axis during cell migration.Current opinion in cell biology · 2011Review
- Self-organization in systems of treadmilling filaments.The European physical journal. E, Soft matter · 2010Article
- Tight functional coupling of kinesin-1A and dynein motors in the bidirectional transport of neurofilaments.Molecular biology of the cell · 2009Article
- Cell biology of embryonic migration.Birth defects research. Part C, Embryo today : reviews · 2008Review
- Kinesin and dynein-dynactin at intersecting microtubules: motor density affects dynein function.Biophysical journal · 2008Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Polarized radial arrays of cytoplasmic microtubules (MTs) with minus ends clustered at the cell center define the organization of the cytoplasm through interaction with microtubule motors bound to membrane organelles or chromosomes. It is generally assumed that the radial organization results from nucleation of MTs at the centrosome. However, radial MT array can also be attained through self-organization that requires the activity of a minus-end-directed MT motor, cytoplasmic dynein. In this study we examine the role of cytoplasmic dynein in the self-organization of a radial MT array in cytoplasmic fragments of fish melanophores lacking the centrosome. After activation of dynein motors bound to membrane-bound organelles, pigment granules, the fragments rapidly form polarized radial arrays of MTs and position pigment aggregates at their centers. We show that rearrangement of MTs in the cytoplasm is achieved through dynein-dependent MT nucleation. The radial pattern is generated by continuous disassembly and reassembly of MTs and concurrent minus-end-directed transport of pigment granules bearing the nucleation sites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.