ArticleProceedings of the National Academy of Sciences of the United States of America2001
Hemocytes are essential for wing maturation in Drosophila melanogaster.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 50 citations in OpenAlex.
- Apoptosis-resistant cells drive compensatory proliferation via cell-autonomous and non-autonomous functions of the initiator caspase Dronc.Nature communications · 2025Article
- Phagocytic hemocytes, independent of pericardial cells, modulate cellular immune responses on the dorsal vessel of mosquitoes, including the infection-induced reduction of the heart rate.Cell and tissue research · 2025Article
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- Growth inhibitory, immunosuppressive, cytotoxic, and genotoxic effects of γ-terpinene on Zeugodacus cucurbitae (Coquillett) (Diptera: Tephritidae).Scientific reports · 2023Article
- Chondroitin sulfate is required for follicle epithelial integrity and organ shape maintenance in Drosophila.Development (Cambridge, England) · 2023Article
- Non-traditional roles of immune cells in regeneration: an evolutionary perspective.Development (Cambridge, England) · 2022Article
- Article
- The essential requirement of an animal heme peroxidase protein during the wing maturation process in Drosophila.BMC developmental biology · 2017Article
- Macrophages and cellular immunity in Drosophila melanogaster.Seminars in immunology · 2015Review
- The canonical Wg signaling modulates Bsk-mediated cell death in Drosophila.Cell death & disease · 2015Article
- Article
- Ontogeny of flight initiation in the fly Drosophila melanogaster: implications for the giant fibre system.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2007Article
- Protein kinase D regulates several aspects of development in Drosophila melanogaster.BMC developmental biology · 2007Article
- Tissue remodeling during maturation of the Drosophila wing.Developmental biology · 2007Article
- A gain-of-function screen identifying genes required for vein formation in the Drosophila melanogaster wing.Genetics · 2006Article
- Embryonic origins of the two main classes of hemocytes--granular cells and plasmatocytes--in Manduca sexta.Development genes and evolution · 2004Article
- Female-specific wing degeneration caused by ecdysteroid in the Tussock Moth, Orgyia recens: hormonal and developmental regulation of sexual dimorphism.Journal of insect science (Online) · 2003Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Newly eclosed flies have wings that are highly folded and compact. Within an hour, each wing has expanded, the dorsal and ventral cuticular surfaces bonding to one another to form the mature wing. To initiate a dissection of this process, we present studies of two mutant phenotypes. First, the batone mutant blocks wing expansion, a behavior that is shown to have a mutant focus anterior to the wing in the embryonic fate map. Second, ectopic expression of protein kinase A catalytic subunit (PKAc) using certain GAL4 enhancer detector strains mimics the batone wing phenotype and also induces melanotic "tumors." Surprisingly, these GAL4 strains express GAL4 in cells, which seem to be hemocytes, found between the dorsal and ventral surfaces of newly opened wings. Ectopic expression of Ricin A in these cells reduces their number and prevents bonding of the wing surfaces without preventing wing expansion. We propose that hemocytes are present in the wing to phagocytose apoptotic epithelial cells and to synthesize an extracellular matrix that bonds the two wing surfaces together. Hemocytes are known to form melanotic tumors either as part of an innate immune response or under other abnormal conditions, including evidently ectopic PKAc expression. Ectopic expression of PKAc in the presence of the batone mutant causes dominant lethality, suggesting a functional relationship. We propose that batone is required for the release of a hormone necessary for wing expansion and tissue remodeling by hemocytes in the wing.
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